Marine Aspergillus: A Treasure Trove of Antimicrobial Compounds

H Li, Y Fu, F Song - Marine Drugs, 2023 - mdpi.com
Secondary metabolites from marine organisms are diverse in structure and function. Marine
Aspergillus is an important source of bioactive natural products. We reviewed the structures …

Recent advances in application of computer-aided drug design in anti-influenza a virus drug discovery

D Yu, L Wang, Y Wang - International Journal of Molecular Sciences, 2022 - mdpi.com
Influenza A is an acute respiratory infectious disease caused by the influenza A virus, which
seriously threatens global human health and causes substantial economic losses every …

Natural Products from Marine Actinomycete Genus Salinispora Might Inhibit 3CLpro and PLpro Proteins of SARS-CoV-2: An In Silico Evidence

O Pokharkar, GV Zyryanov, MV Tsurkan - Microbiology Research, 2023 - mdpi.com
Among the oldest marine species on the planet, the genus Salinispora is often encountered
inhabiting sediments and other marine creatures in tropical and subtropical marine settings …

Pharmacophore-based virtual screening, molecular docking and molecular dynamics studies for the discovery of novel neuraminidase inhibitors

B Lotfi, O Mebarka, SU Khan, TT Htar - Journal of Biomolecular …, 2024 - Taylor & Francis
The in silico evaluation of 27 p-aminosalicylic acid derivatives, also referred to as
neuraminidase inhibitors was the focus of the current study. To search and predict new …

Design, synthesis, and biological evaluation of novel penindolone derivatives as potential inhibitors of hemagglutinin-mediated membrane fusion

B Li, L Huang, J Lin, X Ma, Y Luo, W Gai, Y Xie… - European Journal of …, 2023 - Elsevier
Abstract Development and design of anti-influenza drugs with novel mechanisms is of great
significance to combat the ongoing threat of influenza A virus (IAV). Hemagglutinin (HA) is …

The global prevalence of highly pathogenic avian influenza A (H5N8) infection in birds: A systematic review and meta-analysis

XY Yang, QL Gong, YJ Li, EB Ata, MJ Hu, YY Sun… - Microbial …, 2023 - Elsevier
The zoonotic pathogen avian influenza A H5N8 causes enormous economic losses in the
poultry industry and poses a serious threat to the public health. Here, we report the first …

Chetomin, a SARS-CoV-2 3C-like Protease (3CLpro) Inhibitor: In Silico Screening, Enzyme Docking, Molecular Dynamics and Pharmacokinetics Analysis

MAA Ibrahim, AHM Abdelrahman, DEM Mohamed… - Viruses, 2023 - mdpi.com
The emergence of the Coronavirus Disease 2019 (COVID-19) pandemic caused by severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to over 6 million deaths …

Screening Marine Microbial Metabolites as Promising Inhibitors of Borrelia garinii: A Structural Docking Approach towards Developing Novel Lyme Disease …

Z Basharat, S Sattar, AA Bahauddin… - BioMed Research …, 2024 - Wiley Online Library
Lyme disease caused by the Borrelia species is a growing health concern in many parts of
the world. Current treatments for the disease may have side effects, and there is also a need …

Screening and identifying natural products with SARS-CoV-2 infection inhibitory activity from medicinal fungi

S Zhao, AS Huang, W Zhang, L Ren, H Wang… - Biosafety and …, 2024 - mednexus.org
The coronavirus disease of 2019 (COVID‐19), a global pandemic caused by the severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), can result in severe health …

Avian cell culture models to study immunomodulatory properties of bioactive products

M Paradowska, A Dunislawska, M Siwek, A Slawinska - Animals, 2022 - mdpi.com
Simple Summary Bioactive products have an effect on the molecular and biochemical
functions of a living organism, causing a physiological response of the given tissue. Such a …