[HTML][HTML] Cell type-specific roles of NF-κB linking inflammation and thrombosis
M Mussbacher, M Salzmann, C Brostjan… - Frontiers in …, 2019 - frontiersin.org
The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …
[HTML][HTML] The role of CD95 and CD95 ligand in cancer
Abstract CD95 (Fas/APO-1) and its ligand, CD95L, have long been viewed as a death
receptor/death ligand system that mediates apoptosis induction to maintain immune …
receptor/death ligand system that mediates apoptosis induction to maintain immune …
[HTML][HTML] Life and death by death receptors
ME Guicciardi, GJ Gores - The FASEB Journal, 2009 - ncbi.nlm.nih.gov
Death receptors are members of the tumor necrosis factor receptor superfamily
characterized by a cytoplasmic region known as the “death domain” that enables the …
characterized by a cytoplasmic region known as the “death domain” that enables the …
[HTML][HTML] RIP1, a kinase on the crossroads of a cell's decision to live or die
N Festjens, T Vanden Berghe, S Cornelis… - Cell Death & …, 2007 - nature.com
Binding of inflammatory cytokines to their receptors, stimulation of pathogen recognition
receptors by pathogen-associated molecular patterns, and DNA damage induce specific …
receptors by pathogen-associated molecular patterns, and DNA damage induce specific …
Prolonged drug selection of breast cancer cells and enrichment of cancer stem cell characteristics
AM Calcagno, CD Salcido, JP Gillet… - Journal of the …, 2010 - academic.oup.com
Background Cancer stem cells are presumed to have virtually unlimited proliferative and self-
renewal abilities and to be highly resistant to chemotherapy, a feature that is associated with …
renewal abilities and to be highly resistant to chemotherapy, a feature that is associated with …
Surviving apoptosis: life–death signaling in single cells
DA Flusberg, PK Sorger - Trends in cell biology, 2015 - cell.com
Tissue development and homeostasis are regulated by opposing pro-survival and pro-death
signals. An interesting feature of the Tumor Necrosis Factor (TNF) family of ligands is that …
signals. An interesting feature of the Tumor Necrosis Factor (TNF) family of ligands is that …
Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment
A role for cellular inhibitors of apoptosis (IAPs [cIAPs]) in preventing CD95 death has been
suspected but not previously explained mechanistically. In this study, we find that the loss of …
suspected but not previously explained mechanistically. In this study, we find that the loss of …
NFκB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP
S Kreuz, D Siegmund, JJ Rumpf, D Samel… - The Journal of cell …, 2004 - rupress.org
Fas (APO-1/CD95) is the prototypic death receptor, and the molecular mechanisms of Fas-
induced apoptosis are comparably well understood. Here, we show that Fas activates NFκB …
induced apoptosis are comparably well understood. Here, we show that Fas activates NFκB …
[HTML][HTML] Mathematical modelling of cell-fate decision in response to death receptor engagement
L Calzone, L Tournier, S Fourquet… - PLoS computational …, 2010 - journals.plos.org
Cytokines such as TNF and FASL can trigger death or survival depending on cell lines and
cellular conditions. The mechanistic details of how a cell chooses among these cell fates are …
cellular conditions. The mechanistic details of how a cell chooses among these cell fates are …
Death receptors
H Wajant - Essays in biochemistry, 2003 - portlandpress.com
Death receptors [Fas/Apo-1/CD95, TNF-R1 [tumour necrosis factor (TNF) receptor 1], DR3
[death receptor 3], TRAIL-R1 [TNF-related apoptosis-inducing ligand receptor 1], TRAIL-R2 …
[death receptor 3], TRAIL-R1 [TNF-related apoptosis-inducing ligand receptor 1], TRAIL-R2 …