Inducible nitric oxide synthase: Regulation, structure, and inhibition

MA Cinelli, HT Do, GP Miley… - Medicinal research …, 2020 - Wiley Online Library
A considerable number of human diseases have an inflammatory component, and a key
mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS) …

[HTML][HTML] Mechanistic insights and perspectives involved in neuroprotective action of quercetin

AK Grewal, TG Singh, D Sharma, V Sharma… - Biomedicine & …, 2021 - Elsevier
Neurodegenerative diseases (NDDs) are the primary cause of disabilities in the elderly
people. Growing evidence indicates that oxidative stress, mitochondrial dysfunction …

A perspective on Nrf2 signaling pathway for neuroinflammation: a potential therapeutic target in Alzheimer's and Parkinson's diseases

S Saha, B Buttari, E Profumo, P Tucci… - Frontiers in cellular …, 2022 - frontiersin.org
Neuroinflammation plays a pivotal role in Alzheimer's disease (AD) and Parkinson's disease
(PD), the leading causes of dementia. These neurological disorders are characterized by the …

Neuroprotective effect of quercetin against the detrimental effects of LPS in the adult mouse brain

A Khan, T Ali, SU Rehman, MS Khan, SI Alam… - Frontiers in …, 2018 - frontiersin.org
Chronic neuroinflammation is responsible for multiple neurodegenerative diseases, such as
Alzheimer's disease, Parkinson's disease, and Huntington's disease. Lipopolysaccharide …

Oxidative stress and neurodegenerative disorders

J Li, WO, W Li, ZG Jiang, HA Ghanbari - International journal of molecular …, 2013 - mdpi.com
Living cells continually generate reactive oxygen species (ROS) through the respiratory
chain during energetic metabolism. ROS at low or moderate concentration can play …

Modulation of chronic inflammation by quercetin: The beneficial effects on obesity

S Sato, Y Mukai - Journal of inflammation research, 2020 - Taylor & Francis
Obesity has become a major risk factor for the development of chronic diseases such as
insulin resistance, type 2 diabetes mellitus, and cardiovascular disease. Moreover, obesity …

Surface-modified engineered exosomes attenuated cerebral ischemia/reperfusion injury by targeting the delivery of quercetin towards impaired neurons

L Guo, Z Huang, L Huang, J Liang, P Wang… - Journal of …, 2021 - Springer
Background The incidence of ischemic stroke in the context of vascular disease is high, and
the expression of growth-associated protein-43 (GAP43) increases when neurons are …

Polyphenols: multipotent therapeutic agents in neurodegenerative diseases

KS Bhullar, HPV Rupasinghe - Oxidative medicine and cellular …, 2013 - Wiley Online Library
Aging leads to numerous transitions in brain physiology including synaptic dysfunction and
disturbances in cognition and memory. With a few clinically relevant drugs, a substantial …

Quercetin lipid nanoparticles functionalized with transferrin for Alzheimer's disease

RGR Pinheiro, A Granja, JA Loureiro… - European Journal of …, 2020 - Elsevier
Quercetin was encapsulated in lipid nanoparticles (SLN and NLC) to take advantage of its
neuroprotective properties in Alzheimer's disease. The nanoparticles were functionalized …

Effects of food-derived bioactive peptides on cognitive deficits and memory decline in neurodegenerative diseases: A review

S Wang, D Sun-Waterhouse, GIN Waterhouse… - Trends in Food Science …, 2021 - Elsevier
Background Memory and cognitive impairments/disorders are the main clinical symptoms of
neurodegenerative diseases. The prevalence of such chronic conditions has increased over …