Juvenile idiopathic arthritis
Juvenile idiopathic arthritis (JIA) is an umbrella term for arthritis of unknown origin, lasting
for> 6 weeks with onset before 16 years of age. JIA is the most common chronic …
for> 6 weeks with onset before 16 years of age. JIA is the most common chronic …
B cells on the stage of inflammation in juvenile idiopathic arthritis: leading or supporting actors in disease pathogenesis?
RA Moura, JE Fonseca - Frontiers in Medicine, 2022 - frontiersin.org
Juvenile idiopathic arthritis (JIA) is a term that collectively refers to a group of chronic
childhood arthritides, which together constitute the most common rheumatic condition in …
childhood arthritides, which together constitute the most common rheumatic condition in …
[PDF][PDF] Effect of Clonally Expanded PD‐1highCXCR5–CD4+ Peripheral T Helper Cells on B Cell Differentiation in the Joints of Patients With Antinuclear Antibody …
J Fischer, J Dirks, J Klaussner, G Haase… - Arthritis & …, 2022 - Wiley Online Library
Objective Antinuclear antibody (ANA)–positive juvenile idiopathic arthritis (JIA) is
characterized by synovial B cell hyperactivity, but the precise role of CD4+ T cells in …
characterized by synovial B cell hyperactivity, but the precise role of CD4+ T cells in …
Novel biomarkers for prediction of outcome and therapeutic response in juvenile idiopathic arthritis
S Rosina, V Natoli, S Santaniello… - Expert review of …, 2021 - Taylor & Francis
Introduction The search for biomarkers in juvenile idiopathic arthritis (JIA) is a promising and
rapidly expanding field of investigation. The biomarkers identified so far may help to dissect …
rapidly expanding field of investigation. The biomarkers identified so far may help to dissect …
IL-21+ CD4+ T helper cells co-expressing IFN-γ and TNF-α accumulate in the joints of antinuclear antibody positive patients with juvenile idiopathic arthritis
J Fischer, J Dirks, G Haase, A Holl-Wieden… - Clinical …, 2020 - Elsevier
Abstract Juvenile Idiopathic Arthritis (JIA) is currently classified into seven subgroups.
Recently, antinuclear antibody (ANA) positive JIA patients were suggested to encompass a …
Recently, antinuclear antibody (ANA) positive JIA patients were suggested to encompass a …
B cells as a therapeutic target in paediatric rheumatic disease
MGL Wilkinson, EC Rosser - Frontiers in immunology, 2019 - frontiersin.org
B cells carry out a central role in the pathogenesis of autoimmune disease. In addition to the
production of autoantibodies, B cells can contribute to disease development by presenting …
production of autoantibodies, B cells can contribute to disease development by presenting …
Predictors of flare following etanercept withdrawal in patients with rheumatoid factor–negative juvenile idiopathic arthritis who reached remission while taking …
A Aquilani, DP Marafon, E Marasco, R Nicolai… - The Journal of …, 2018 - jrheum.org
Objective. To evaluate the rate of flare after etanercept (ETN) withdrawal in patients with
juvenile idiopathic arthritis (JIA) who attained clinical remission while taking medication, and …
juvenile idiopathic arthritis (JIA) who attained clinical remission while taking medication, and …
Acquired B-cell deficiency secondary to B-cell-depleting therapies
A Blincoe, R Labrosse, RS Abraham - Journal of Immunological Methods, 2022 - Elsevier
The advantage of the newer biological therapies is that the immunosuppressive effect is
targeted, in contrast, to the standard, traditional immunomodulatory agents, which have a …
targeted, in contrast, to the standard, traditional immunomodulatory agents, which have a …
The ISCCA flow protocol for the monitoring of anti‐CD20 therapies in autoimmune disorders
A Gatti, F Buccisano, MT Scupoli… - Cytometry Part B …, 2021 - Wiley Online Library
Abstract Background Anti‐CD20 monoclonals (MoAbs) are used in a variety of autoimmune
disorders. The aim is to eliminate memory B cells sustaining the tissue damage and the …
disorders. The aim is to eliminate memory B cells sustaining the tissue damage and the …
Frequency of CD19+CD24hiCD38hi regulatory B cells is decreased in peripheral blood and synovial fluid of patients with juvenile idiopathic arthritis: a preliminary …
Q Zhao, LK Jung - Pediatric Rheumatology, 2018 - Springer
Background To understand the relationship between regulatory B cells (Bregs) and juvenile
idiopathic arthritis (JIA), we analyzed the percentages of Bregs and their function in …
idiopathic arthritis (JIA), we analyzed the percentages of Bregs and their function in …