Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene
silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be …

The relationships between chromosomal compartmentalization, chromatin state and function
are poorly understood. Here by profiling long-range contact frequencies in HCT116 colon …

DNA methylation acts as an epigenetic modification in vertebrate DNA. Recently it has
become clear that the DNA and histone lysine methylation systems are highly interrelated …

Epigenetic modifications are heritable changes in gene expression not encoded by the DNA
sequence. In the past decade, great strides have been made in characterizing epigenetic …

Senescence refers to a cellular state featuring a stable cell‐cycle arrest triggered in
response to stress. This response also involves other distinct morphological and intracellular …

Both DNA methylation and histone modification are involved in establishing patterns of gene
repression during development. Certain forms of histone methylation cause local formation …

Our current view of DNA methylation processes is strongly moving: First, even if it was
generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and …

DNA methylation patterns are set up early in mammalian development and are then copied
during the division of somatic cells. A long-established model for the maintenance of these …

DNA methylation is an important epigenetic mark involved in diverse biological processes.
In plants, DNA methylation can be established through the RNA-directed DNA methylation …