IFNγ released from CD8+ T cells or natural killer cells plays a crucial role in antitumor host
immunity. Several studies have found that IFNγ is involved in regulating tumor cell …

Conventional chemotherapy is the main treatment for cancer and benefits patients in the
form of decreased relapse and metastasis and longer overall survival. However, as the …

Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer
therapies, thereby limiting their effectiveness,,,. A high-mesenchymal cell state observed in …

Cancer stem cells (CSCs) represent a subset of cells within tumours that exhibit self-renewal
properties and the capacity to seed tumours. CSCs are typically refractory to conventional …

Abstract Changes in cellular gene expression in response to small-molecule or genetic
perturbations have yielded signatures that can connect unknown mechanisms of action …

Most tumours have an aberrantly activated lipid metabolism, that enables them to
synthesize, elongate and desaturate fatty acids to support proliferation. However, only …

Epithelial-to-mesenchymal transition (EMT) promotes both tumor progression and drug
resistance, yet few vulnerabilities of this state have been identified. Using selective small …

The increasing incidence of resistance to chemotherapeutic agents has become a major
issue in the treatment of oral cancer (OC). Epithelial-mesenchymal transition (EMT) has …

The enthusiasm for phenotypic screening as an approach for small-molecule discovery has
increased dramatically over the last several years. The recent increase in phenotype-based …

Cancer stem cells (CSC) or tumor-initiating cells represent a small subpopulation of cells
within the tumor bulk that share features with somatic stem cells, such as self-renewal and …