Understanding how transcriptional enhancers control over 20,000 protein-coding genes to
maintain cell-type-specific gene expression programs in all human cells is a fundamental …

Whole-genome sequence assemblies are now available for seven different animals,
including nematode worms, mice and humans. Comparative genome analyses reveal a …

How enhancers control target gene expression over long genomic distances remains an
important unsolved problem. Here we investigated enhancer–promoter communication by …

Gene expression in mammals is regulated by noncoding elements that can affect physiology
and disease, yet the functions and target genes of most noncoding elements remain …

Transcription is episodic, consisting of a series of discontinuous bursts. Using live-imaging
methods and quantitative analysis, we examine transcriptional bursting in living Drosophila …

Transcription factor Nrf2 is essential for the antioxidant responsive element (ARE)-mediated
induction of phase II detoxifying and oxidative stress enzyme genes. Detailed analysis of …

In the new edition of this successful and authoritative book, the thalassaemias are reviewed
in detail with respect to their clinical features, cellular pathology, molecular genetics …

We suggest a model in which a hierarchy of controls is exerted on the family of odorant
receptor genes to assure that a sensory neuron expresses a single receptor from a family of …

The mechanisms by which mammals discriminate a vast array of diverse odors are poorly
understood. To gain insight into the organizational strategies underlying this discriminatory …

The term 'transcriptional interference'(TI) is widely used but poorly defined in the literature.
There are a variety of methods by which one can interfere with the process or the product of …