Drug repurposing: the mechanisms and signaling pathways of anti-cancer effects of anesthetics

KC Wu, KS Liao, LR Yeh, YK Wang - Biomedicines, 2022 - mdpi.com
Cancer is one of the leading causes of death worldwide. There are only limited treatment
strategies that can be applied to treat cancer, including surgical resection, chemotherapy …

Forkhead box transcription factors (FOXOs and FOXM1) in glioma: from molecular mechanisms to therapeutics

P Tabnak, A Hasanzade Bashkandi… - Cancer Cell …, 2023 - Springer
Glioma is the most aggressive and malignant type of primary brain tumor, comprises the
majority of central nervous system deaths, and is categorized into different subgroups …

Programmable readout sensor for microRNA: CRISPR/Cas12a-assisted multi-amplification strategy activated photoelectrochemistry-colorimetry detection

H Shen, H Yang, A Qileng, Y Ma, H Liang… - Sensors and Actuators B …, 2022 - Elsevier
The microRNA (miRNA) has a unique physiological regulation function in tissues, thus its
expression level can reflect the development of various diseases. Nevertheless, due to the …

Towards unravelling the role of ERα-targeting miRNAs in the exosome-mediated transferring of the hormone resistance

OE Andreeva, DV Sorokin, EI Mikhaevich, IV Bure… - Molecules, 2021 - mdpi.com
Hormone therapy is one of the most effective breast cancer treatments, however, its
application is limited by the progression of hormonal resistance, both primary or acquired …

CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers

J Sun, H Ren, J Wang, X Xiao, L Zhu… - Frontiers in Cell and …, 2024 - frontiersin.org
CHAC1, an essential regulator of oxidative stress and ferroptosis, is increasingly recognized
for its significant roles in these cellular processes and its impact on various human diseases …

Potential therapeutic action of autophagy in gastric cancer managements: Novel treatment strategies and pharmacological interventions

MA Rahman, KR Ahmed, MDH Rahman… - Frontiers in …, 2022 - frontiersin.org
Gastric cancer (GC), second most leading cause of cancer-associated mortality globally, is
the cancer of gastrointestinal tract in which malignant cells form in lining of the stomach …

A review on the roles and molecular mechanisms of MAFG-AS1 in oncogenesis

KG Dabbaghi, N Mashatan, O Faraz… - … -Research and Practice, 2023 - Elsevier
Long non-coding RNAs (lncRNAs) have more than 200 nucleotides and do not encode
proteins. At the same time, they can regulate various biological functions and therefore play …

Natural products in suppressing glioma progression: a focus on the role of microRNAs

P Tabnak, S Masrouri, A Mafakheri - Phytotherapy Research, 2022 - Wiley Online Library
Glioma is one of the most common malignancies of the central nervous system. Due to
inadequate response to the current treatments available, glioma has been at the center of …

Sensitive detection of miR-122 via toehold-promoted strand displacement reaction and enzyme-assisted cycle amplification

P Ouyang, Y Qing, S Zou, C Fang, J Han… - Biochemical …, 2022 - Elsevier
It is of great significance to develop a sensitive detection platform for miRNA, a non-invasive
biological indicator for the diagnosis, treatment and prognosis monitoring of tumors. In this …

Impact of local anesthetics on epigenetics in cancer

L Bezu, O Kepp, G Kroemer - Frontiers in oncology, 2022 - frontiersin.org
Defective silencing of tumor suppressor genes through epigenetic alterations contributes to
oncogenesis by perturbing cell cycle regulation, DNA repair or cell death mechanisms …