Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update
N Takebe, L Miele, PJ Harris, W Jeong… - Nature reviews Clinical …, 2015 - nature.com
During the past decade, cancer stem cells (CSCs) have been increasingly identified in many
malignancies. Although the origin and plasticity of these cells remain controversial, tumour …
malignancies. Although the origin and plasticity of these cells remain controversial, tumour …
Signaling by the phosphoinositide 3-kinase family in immune cells
K Okkenhaug - Annual review of immunology, 2013 - annualreviews.org
Phosphoinositide 3-kinases (PI3Ks) control many important aspects of immune cell
development, differentiation, and function. Mammals have eight PI3K catalytic subunits that …
development, differentiation, and function. Mammals have eight PI3K catalytic subunits that …
[HTML][HTML] Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections
A cardinal feature of COVID-19 is lung inflammation and respiratory failure. In a prospective
multi-country cohort of COVID-19 patients, we found that increased Notch4 expression on …
multi-country cohort of COVID-19 patients, we found that increased Notch4 expression on …
Notch in T cell differentiation: all things considered
D Amsen, C Helbig, RA Backer - Trends in immunology, 2015 - cell.com
Differentiation of naïve T cells into effector cells is required for optimal protection against
different classes of microbial pathogen and for the development of immune memory. Recent …
different classes of microbial pathogen and for the development of immune memory. Recent …
Control of peripheral tolerance by regulatory T cell–intrinsic Notch signaling
Receptors of the Notch family direct the differentiation of helper T cell subsets, but their
influence on regulatory T cell (T reg cell) responses is obscure. We found here that lineage …
influence on regulatory T cell (T reg cell) responses is obscure. We found here that lineage …
Transcriptional regulation of innate and adaptive lymphocyte lineages
ME De Obaldia, A Bhandoola - Annual review of immunology, 2015 - annualreviews.org
The lymphocyte family has expanded significantly in recent years to include not only the
adaptive lymphocytes (T cells, B cells) and NK cells, but also several additional innate …
adaptive lymphocytes (T cells, B cells) and NK cells, but also several additional innate …
A review of notch processing with new insights into ligand-independent notch signaling in T-cells
MP Steinbuck, S Winandy - Frontiers in immunology, 2018 - frontiersin.org
The Notch receptor is an evolutionarily highly conserved transmembrane protein essential to
a wide spectrum of cellular systems, and its deregulation has been linked to a vast number …
a wide spectrum of cellular systems, and its deregulation has been linked to a vast number …
Notch signaling regulates mitochondrial metabolism and NF-κB activity in triple-negative breast cancer cells via IKKα-dependent non-canonical pathways
F Hossain, C Sorrentino, DA Ucar, Y Peng… - Frontiers in …, 2018 - frontiersin.org
Triple negative breast cancer (TNBC) patients have high risk of recurrence and metastasis,
and current treatment options remain limited. Cancer stem-like cells (CSCs) have been …
and current treatment options remain limited. Cancer stem-like cells (CSCs) have been …
Breast cancer stem cells
JS Crabtree, L Miele - Biomedicines, 2018 - mdpi.com
Breast cancer stem cells (BCSC) have been implicated in tumor initiation, progression,
metastasis, recurrence, and resistance to therapy. The origins of BCSCs remain …
metastasis, recurrence, and resistance to therapy. The origins of BCSCs remain …
Growth factor-dependent and-independent activation of mTORC2
The target of rapamycin complex 2 (TORC2) was discovered in 2002 in budding yeast. Its
mammalian counterpart, mTORC2, was first described in 2004. Soon thereafter it was …
mammalian counterpart, mTORC2, was first described in 2004. Soon thereafter it was …