Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Mitochondria are organelles involved in the regulation of various important cellular
processes, ranging from ATP generation to immune activation. A healthy mitochondrial …

Autophagy contributes to the maintenance of intracellular homeostasis in most cells of
cardiovascular origin, including cardiomyocytes, endothelial cells, and arterial smooth …

Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an
attractive drug target in numerous maladies that range from heart disease to …

Autophagy is an evolutionarily conserved mechanism by which cytoplasmic elements are
degraded intracellularly. Autophagy has also emerged as a major regulator of cardiac …

Adenosine monophosphate-activated protein kinase (AMPK) is in charge of numerous
catabolic and anabolic signaling pathways to sustain appropriate intracellular adenosine …

Rationale: Mitochondrial dysfunction plays an important role in heart failure (HF). However,
the molecular mechanisms regulating mitochondrial functions via selective mitochondrial …

A large body of evidence indicates that mitochondrial dysfunction has a major role in the
pathogenesis of multiple cardiovascular disorders. Over the past 2 decades, extraordinary …

The process of mitochondrial dynamics is emerging as a core player in cardiovascular
homeostasis. This process refers to the co‐ordinated cycles of biogenesis, fusion, fission …

Healthy mitochondrial function is imperative for most tissues, but especially those with a high
energy demand. Robust evidence linking mitochondrial dysfunction with cardiovascular …