Opioid receptors have been targeted for the treatment of pain and related disorders for
thousands of years and remain the most widely used analgesics in the clinic. Mu (μ), kappa …

In the past two decades a trickle of manuscripts examining the non-neuronal central nervous
system immune consequences of the drugs of abuse has now swollen to a significant body …

Assembly of synapses requires proper coordination between pre-and postsynaptic
elements. Identification of cellular and molecular events in synapse formation and …

Astrocytes limit inflammation after CNS injury, at least partially by physically containing it
within an astrocytic scar at the injury border. We report here that astrocytic transforming …

Clinical and preclinical studies indicate that adaptations in corticostriatal neurotransmission
significantly contribute to heroin relapse vulnerability. In animal models, heroin self …

Astrocytes are critical in synapse development, and their dysfunction in crucial
developmental stages leads to serious neurodevelopmental diseases, including seizures …

Opioid exposure is known to cause transcriptomic changes in the nucleus accumbens
(NAc). However, no studies to date have investigated cell type-specific transcriptomic …

Transforming growth factor-β (TGF-β) belongs to a group of pleiotropic cytokines that are
involved in a variety of biological processes, such as inflammation and immune reactions …

Alzheimer's disease (AD) is an incurable neurodegenerative disease characterised clinically
by learning and memory impairments. Amyloid beta (Aβ) peptide-induced synaptic …

Addiction is a leading cause of disease burden worldwide and remains a challenge in
current neuroscience research. Drug-induced lasting changes in gene expression are …