Primary cilia as dynamic and diverse signalling hubs in development and disease

P Mill, ST Christensen, LB Pedersen - Nature Reviews Genetics, 2023 - nature.com
Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate
cell types, are essential for regulating signalling pathways during development and adult …

Stimuli-responsive polymer-based nanosystems for cancer theranostics

D Wei, Y Sun, H Zhu, Q Fu - ACS nano, 2023 - ACS Publications
Stimuli-responsive polymers can respond to internal stimuli, such as reactive oxygen
species (ROS), glutathione (GSH), and pH, biological stimuli, such as enzymes, and external …

Ångström-resolution fluorescence microscopy

SCM Reinhardt, LA Masullo, I Baudrexel, PR Steen… - Nature, 2023 - nature.com
Fluorescence microscopy, with its molecular specificity, is one of the major characterization
methods used in the life sciences to understand complex biological systems. Super …

Real-time denoising enables high-sensitivity fluorescence time-lapse imaging beyond the shot-noise limit

X Li, Y Li, Y Zhou, J Wu, Z Zhao, J Fan, F Deng… - Nature …, 2023 - nature.com
A fundamental challenge in fluorescence microscopy is the photon shot noise arising from
the inevitable stochasticity of photon detection. Noise increases measurement uncertainty …

Super-resolution microscopy for structural cell biology

S Liu, P Hoess, J Ries - Annual review of biophysics, 2022 - annualreviews.org
Super-resolution microscopy techniques, and specifically single-molecule localization
microscopy (SMLM), are approaching nanometer resolution inside cells and thus have great …

Endosomal escape: A bottleneck for LNP-mediated therapeutics

S Chatterjee, E Kon, P Sharma… - Proceedings of the …, 2024 - National Acad Sciences
Lipid nanoparticles (LNPs) have recently emerged as a powerful and versatile clinically
approved platform for nucleic acid delivery, specifically for mRNA vaccines. A major …

The new era of high-throughput nanoelectrochemistry

X Xu, D Valavanis, P Ciocci, S Confederat… - Analytical …, 2023 - ACS Publications
To acquire a deeper understanding of electrochemical systems requires techniques that
address nanoscale aspects of electrochemistry, inter alia, the detection and analysis of …

Small-molecule fluorogenic probes for mitochondrial nanoscale imaging

R Zhai, B Fang, Y Lai, B Peng, H Bai, X Liu… - Chemical Society …, 2023 - pubs.rsc.org
Mitochondria are inextricably linked to the development of diseases and cell metabolism
disorders. Super-resolution imaging (SRI) is crucial in enhancing our understanding of …

Small size, big impact: recent progress in bottom‐up synthesized nanographenes for optoelectronic and energy applications

Z Liu, S Fu, X Liu, A Narita, P Samorì, M Bonn… - Advanced …, 2022 - Wiley Online Library
Bottom‐up synthesized graphene nanostructures, including 0D graphene quantum dots and
1D graphene nanoribbons, have recently emerged as promising candidates for efficient …

Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus

BA Lloyd, Y Han, R Roth, B Zhang, J Aoto - Nature Communications, 2023 - nature.com
Proteins critical for synaptic transmission are non-uniformly distributed and assembled into
regions of high density called subsynaptic densities (SSDs) that transsynaptically align in …