Traumatic brain injury (TBI) is a heterogeneous disorder that involves brain damage due to
external forces. TBI is the main factor of death and morbidity in young males with a high …

Traumatic brain injury (TBI) leads to multiple short-and long-term changes in neuronal
circuits that ultimately conclude with an imbalance of cortical excitation and inhibition …

Epilepsy is broadly characterized by aberrant neuronal excitability. Glutamate is the
predominant excitatory neurotransmitter in the adult mammalian brain; thus, much of past …

Epilepsy is a complex neurological syndrome characterized by seizures resulting from
neuronal hyperexcitability and sudden and synchronized bursts of electrical discharges …

Epilepsy is a common brain disorder, characterized by spontaneous recurrent seizures, with
associated neuropsychiatric and cognitive comorbidities and increased mortality. Although …

GLT-1 (EAAT2; slc1a2) is the major glutamate transporter in the brain, and is predominantly
expressed in astrocytes, but at lower levels also in excitatory terminals. We generated a …

Research on glial cells over the past 30 years has confirmed the critical role of astrocytes in
pathophysiological brain states. However, most of our knowledge about astrocyte …

Excitatory amino acid transporters (EAATs) encompass a class of five transporters with
distinct expression in neurons and glia of the central nervous system (CNS). EAATs are …

Descriptions of epileptic seizures and epilepsy date back to antiquity, and research into
fundamental mechanisms of epilepsy in animal models, as well as patients, has been …

Glutamate is the predominant excitatory neurotransmitter in the central nervous system.
Excitatory amino acid transporter 2 (EAAT2) is primarily responsible for clearance of …