NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

Abstract NEDD8-conjugating enzymes, E2s, include the well-studied ubiquitin-conjugating
enzyme E2 M (UBE2M) and the poorly characterized ubiquitin-conjugating enzyme E2 F …

Neddylation is a post-translational mechanism that adds a ubiquitin-like protein, namely
neural precursor cell expressed developmentally downregulated protein 8 (NEDD8). Here …

Oxidative stress, infection, and vasculopathy caused by hyperglycemia are the main barriers
for the rapid repair of foot ulcers in patients with diabetes mellitus (DM). In recent times, the …

Besides abstinence, no effective treatment exists for alcohol-related liver disease (ALD), a
dreaded consequence of alcohol abuse. In this study, we assessed the roles on ALD of dual …

Aging in humans is associated with abdominal distribution and remodeling of body fat and a
parallel gradual increase in the prevalence of metabolic diseases such as obesity, type 2 …

Cullin RING E3 ligases (CRL) have emerged as key regulators of disease-modifying
pathways and therapeutic targets. Cullin3 (Cul3)-containing CRL (CRL3) has been …

Diabetic sensory neuropathy (DSN) is one of the most common complications of type 2
diabetes (T2D), however the molecular mechanistic association between T2D and DSN …

Background Neddylation, an important post-translational modification (PTM) of proteins,
plays a crucial role in follicular development. MLN4924 is a small-molecule inhibitor of the …

Pancreatic development is orchestrated by timely synthesis and degradation of stage‐
specific transcription factors (TFs). The transition from one stage to another stage is …