TERRA transcripts localize at long telomeres to regulate telomerase access to chromosome ends
N Bettin, E Querido, I Gialdini, GP Grupelli, E Goretti… - Science …, 2024 - science.org
The function of TERRA in the regulation of telomerase in human cells is still debated. While
TERRA interacts with telomerase, how it regulates telomerase function remains unknown …
TERRA interacts with telomerase, how it regulates telomerase function remains unknown …
Long Telomeric Repeat-Containing RNA (TERRA): Biological Functions and Challenges in Vascular Aging and Disease
Telomere dysfunction is implicated in vascular aging and shorter leucocyte telomeres are
associated with an increased risk of atherosclerosis, myocardial infarction, and heart failure …
associated with an increased risk of atherosclerosis, myocardial infarction, and heart failure …
TERRA ONTseq: a long-read-based sequencing pipeline to study the human telomeric transcriptome
J Rodrigues, R Alfieri, S Bione, CM Azzalin - RNA, 2024 - rnajournal.cshlp.org
The long noncoding RNA TERRA is transcribed from telomeres in virtually all eukaryotes
with linear chromosomes. In humans, TERRA transcription is driven in part by promoters …
with linear chromosomes. In humans, TERRA transcription is driven in part by promoters …
Senolytics and cell senescence: historical and evolutionary perspectives
CE Finch - Evolution, Medicine, and Public Health, 2024 - academic.oup.com
Senolytics are a new class of anti-aging drugs developed to selectively kill 'senescent'cells
that are considered harmful in normal aging. More than 20 drug trials are ongoing with …
that are considered harmful in normal aging. More than 20 drug trials are ongoing with …