Cardiac alternans: from bedside to bench and back

Z Qu, JN Weiss - Circulation research, 2023 - Am Heart Assoc
Cardiac alternans arises from dynamical instabilities in the electrical and calcium cycling
systems of the heart, and often precedes ventricular arrhythmias and sudden cardiac death …

Role of Reduced Sarco-Endoplasmic Reticulum Ca2+-ATPase Function on Sarcoplasmic Reticulum Ca2+ Alternans in the Intact Rabbit Heart

L Wang, RC Myles, IJ Lee, DM Bers… - Frontiers in …, 2021 - frontiersin.org
Sarcoplasmic reticulum (SR) Ca2+ cycling is tightly regulated by ryanodine receptor (RyR)
Ca2+ release and sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) Ca2+ uptake …

[HTML][HTML] Excitation–contraction coupling in cardiac, skeletal, and smooth muscle

RT Dirksen, DA Eisner, E Ríos, KR Sipido - 2022 - rupress.org
The term “excitation–contraction (EC) coupling” was introduced by Alexander Sandow
(Sandow, 1952) as “the entire sequence of reactions—excitation, inward acting link, and …

Synchronization of spatially discordant voltage and calcium alternans in cardiac tissue

C Huang, Z Song, Z Qu - Physical Review E, 2022 - APS
The heart is an excitable medium which is excited by membrane potential depolarization
and propagation. Membrane potential depolarization brings in calcium (Ca) through the Ca …

The calcium transient coupled to the L-type calcium current attenuates cardiac alternans

M Warren, S Poelzing - Frontiers in Physiology, 2024 - frontiersin.org
Cardiac action potential (AP) alternans have been linked to the development of arrhythmia.
AP alternans may be driven by AP instabilities, Ca2+ transient (CaT) instabilities, or both …

Prolonged Ca2+ release refractoriness and T‐tubule disruption as determinants of increased propensity to cardiac alternans in the hypertensive heart disease

JIE Mariángelo, GD Di Marzio, LA Gonano… - Acta …, 2023 - Wiley Online Library
Aim Cardiac alternans is a dynamical phenomenon linked to the genesis of severe
arrhythmias and sudden cardiac death. It has been proposed that alternans is caused by …

The Calcium Transient Coupled to the L-Type Calcium Current Attenuates Action Potential Alternans

M Warren, S Poelzing - bioRxiv, 2023 - biorxiv.org
Background Action potential (AP) alternans are linked to increased arrhythmogenesis. It is
suggested that calcium (Ca2+) transient (CaT) alternans cause AP alternans through bi …

[PDF][PDF] Expresión del sensor de calcio intrasarcoplasmático (r-cepia-er) en miocitos cardíacos

A Arjez - 2024 - repositorio.unnoba.edu.ar
Junto con la realización de esta tesis concluye una etapa de muchos años de aprendizajes,
tanto académicos como personales, que abren lugar a una carrera profesional que recién …

Rol fisiopatológico del receptor de estrógenos acoplado a proteína G (GPER) en la electrofisiología cardíaca

LA Diaz Zegarra - 2023 - sedici.unlp.edu.ar
Universidad Nacional de La Plata Trabajo de Tesis Doctoral Page 1 1 Universidad Nacional de
La Plata Facultad de Ciencias Exactas Departamento de Ciencias Biológicas Trabajo de Tesis …

Señales de Ca2+ en el retículo sarcoplasmático cardiaco y señales mitocondriales en la isquemia y reperfusión

DCA Cely Ortiz - 2023 - sedici.unlp.edu.ar
El infarto de miocardio (IM) constituye una causa principal de morbilidad y mortalidad en los
países occidentales (Mozaffarian D, 2016) y en el mundo (OMS, 2020). Ocurre debido a la …