Presence of a fovea centralis is directly linked to molecular specification of an avascular
area in central retina, before the fovea (or 'pit') begins to form. Modelling suggests that …

Albinism is a pigment disorder affecting eye, skin and/or hair. Patients usually have
decreased melanin in affected tissues and suffer from severe visual abnormalities, including …

Mutations in pre-mRNA processing factors (PRPFs) cause autosomal-dominant retinitis
pigmentosa (RP), but it is unclear why mutations in ubiquitously expressed genes cause non …

Human stem-cell derivatives are likely to play an important role in the future of regenerative
medicine. Evaluation and comparison to their in vivo counterparts is critical for assessment …

Pigment epithelium-derived factor (PEDF) is a potent and broadly acting neurotrophic factor
that protects neurons in many regions of the central nervous system against insults such as …

Healthy Retinal Pigment Epithelium (RPE) cells are required for proper visual function and
the phenomenon of RPE derivation from Human Embryonic Stem Cells (HESC) holds great …

It has been shown that the balance between vascular endothelial growth factor (VEGF), a
major angiogenic stimulator, and pigment epithelium-derived factor (PEDF), a potent …

purpose. To evaluate the impact of photodynamic therapy (PDT) on expression and
distribution of vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)-3, and …

Pigment epithelium-derived factor (PEDF) is an extracellular multifunctional protein
belonging to the serpin superfamily with demonstrable neurotrophic, gliastatic …

Corneal avascularity is necessary for the preservation of optimal vision. The cornea
maintains a dynamic balance between pro-and antiangiogenic factors that allows it to …