The assembly and maturation of the mammalian brain result from an intricate cascade of
highly coordinated developmental events, such as cell proliferation, migration, and …

Brain size is controlled by several factors during neuronal development, including neural
progenitor proliferation, neuronal arborization, gliogenesis, cell death, and synaptogenesis …

The three-dimensional genome structure organized by CTCF is required for development.
Clinically identified mutations in CTCF have been linked to adverse developmental …

Diabetic keratopathy (DK), the diabetic complication in the cornea, is characterized by the
delayed epithelial regeneration and sensory nerve degeneration. The involvement of limbal …

Appropriate histone modifications emerge as essential cell fate regulators of neuronal
identities across neocortical areas and layers. Here we showed that NSD1, the …

The β-catenin-dependent canonical Wnt signaling is pivotal in organ development, tissue
homeostasis, and cancer. Here, we identified an upstream enhancer of Ctnnb1–the coding …

The covalent modification of histones is critical for many biological functions in mammals,
including gene regulation and chromatin structure. Posttranslational histone modifications …

Patients with polycystic kidney disease (PKD) encounter a high risk of clear cell renal cell
carcinoma (ccRCC), a malignant tumor with dysregulated lipid metabolism. SET domain …

SETD2 belongs to the family of histone methyltransferase proteins and has been associated
with three nosologically distinct entities with different clinical and molecular features: Luscan …

The etiology of neurodevelopmental disorders (NDDs) remains a challenge for researchers.
Human brain development is tightly regulated and sensitive to cellular alterations caused by …