The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear
pore complexes. Laminopathies are diseases caused by mutations in genes encoding …

The modification of eukaryotic proteins by isoprenoid lipids, which is known as prenylation,
controls the localization and activity of a range of proteins that have crucial functions in …

The nuclear lamina is an important structural determinant for the nuclear envelope as a
whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear …

Products of the LMNA gene, primarily lamin A and C, are key components of the nuclear
lamina, a proteinaceous meshwork that underlies the inner nuclear membrane and is …

Protein farnesylation and geranylgeranylation, together referred to as prenylation, are lipid
post-translational modifications that are required for the transforming activity of many …

RAS has long been viewed as undruggable due to its lack of deep pockets for binding of
small molecule inhibitors. However, recent successes in the development of direct RAS …

Over the past few years it has become evident that the intermediate filament proteins, the
types A and B nuclear lamins, not only provide a structural framework for the nucleus, but …

Aging is characterized by an increasing morbidity and functional decline that eventually
results in the death of an organism. Aging is the largest risk factor for numerous human …

The RAS oncogenes (HRAS, NRAS and KRAS) comprise the most frequently mutated class
of oncogenes in human cancers (33%), thus stimulating intensive effort in developing anti …

Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare, fatal, segmental
premature aging syndrome caused by a mutation in LMNA that produces the farnesylated …