In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

The scientific study of protein surfactant interactions goes back more than a century, and has
been put to practical uses in everything from the estimation of protein molecular weights to …

Interactions between solvents and solutes are a cornerstone of physical organic chemistry
and have been the subject of investigations over the last century. In recent years, a renewed …

The design of modular protein logic for regulating protein function at the posttranscriptional
level is a challenge for synthetic biology. Here, we describe the design of two-input AND …

Our goal was to gain a better understanding of the contribution of the burial of polar groups
and their hydrogen bonds to the conformational stability of proteins. We measured the …

A major challenge of computational protein design is the creation of novel proteins with
arbitrarily chosen three-dimensional structures. Here, we used a general computational …

Proteins are marginally stable, and the folding/unfolding equilibrium of proteins in aqueous
solution can easily be altered by the addition of small organic molecules known as …

The lamprey holds the clue to the link between supramolecular self-assembly and allosteric
ligand binding. Chelate cooperativity in self-assembled structures results in denaturation …

There are still debates on whether the hydration of ions perturbs the water structure, and
what is the degree of such disturbance; therefore, the origin of the Hofmeister effect on …

Theoretical studies have suggested relationships between the size, stability and topology of
a protein fold and the rate and mechanisms by which it is achieved. The recent …