[HTML][HTML] Aptamers in the therapeutics and diagnostics pipelines
Aptamers are short single-stranded DNA or RNA oligonucleotides that can selectively bind
to small molecular ligands or protein targets with high affinity and specificity, by acquiring …
to small molecular ligands or protein targets with high affinity and specificity, by acquiring …
Conjugation of antibodies and aptamers on nanozymes for developing biosensors
Nanozymes are engineered nanomaterials with enzyme-like activities. Over the past
decade, impressive progresses on nanozymes in biosensing have been made due to their …
decade, impressive progresses on nanozymes in biosensing have been made due to their …
Aptamer-mediated colorimetric and electrochemical detection of Pseudomonas aeruginosa utilizing peroxidase-mimic activity of gold NanoZyme
Despite of various advancements in biosensing, a rapid, accurate, and on-site detection of a
bacterial pathogen is a real challenge due to the lack of appropriate diagnostic platforms. To …
bacterial pathogen is a real challenge due to the lack of appropriate diagnostic platforms. To …
SELEX: Critical factors and optimization strategies for successful aptamer selection
M Kohlberger, G Gadermaier - Biotechnology and applied …, 2022 - Wiley Online Library
Within the last decade, the application range of aptamers in biochemistry and medicine has
expanded rapidly. More than just a replacement for antibodies, these intrinsically structured …
expanded rapidly. More than just a replacement for antibodies, these intrinsically structured …
Aptamers in biomedicine: Selection strategies and recent advances
Aptamers have come in the spotlight as bio-mimetic molecular recognition elements in the
field of biomedicine due to various applications in diagnostics, drug delivery, therapeutics …
field of biomedicine due to various applications in diagnostics, drug delivery, therapeutics …
Aptamer-based point-of-care diagnostic platforms
A Dhiman, P Kalra, V Bansal, JG Bruno… - Sensors and Actuators B …, 2017 - Elsevier
This review covers a broad range of well-established and novel diagnostic platforms which
are currently being considered for use in commercial point-of care (POC) diagnostics …
are currently being considered for use in commercial point-of care (POC) diagnostics …
Simple methods and rational design for enhancing aptamer sensitivity and specificity
P Kalra, A Dhiman, WC Cho, JG Bruno… - Frontiers in molecular …, 2018 - frontiersin.org
Aptamers are structured nucleic acid molecules that can bind to their targets with high affinity
and specificity. However, conventional SELEX (Systematic Evolution of Ligands by …
and specificity. However, conventional SELEX (Systematic Evolution of Ligands by …
Self-Assembled Multivalent Aptamer Drug Conjugates: Enhanced Targeting and Cytotoxicity for HER2-Positive Gastric Cancer
W Ma, Y Yang, Z Liu, R Zhao, Q Wan… - … Applied Materials & …, 2023 - ACS Publications
Antibody drug conjugates (ADCs) have shown promise to be the mainstream
chemotherapeutics for advanced HER2-positive cancers, yet the issues of poor drug …
chemotherapeutics for advanced HER2-positive cancers, yet the issues of poor drug …
Materials and microfluidics: enabling the efficient isolation and analysis of circulating tumour cells
JM Jackson, MA Witek, JW Kamande… - Chemical Society …, 2017 - pubs.rsc.org
We present a critical review of microfluidic technologies and material effects on the analyses
of circulating tumour cells (CTCs) selected from the peripheral blood of cancer patients …
of circulating tumour cells (CTCs) selected from the peripheral blood of cancer patients …
A novel G-quadruplex aptamer-based spike trimeric antigen test for the detection of SARS-CoV-2
The recent SARS-CoV-2 outbreak has been declared a global health emergency. It will take
years to vaccinate the whole population to protect them from this deadly virus, hence the …
years to vaccinate the whole population to protect them from this deadly virus, hence the …