As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …

The adult mammalian heart contains abundant interstitial and perivascular fibroblasts that
expand following injury and play a reparative role but also contribute to maladaptive fibrotic …

The term 'mechanosensation'describes the capacity of cells to translate mechanical stimuli
into the coordinated regulation of intracellular signals, cellular function, gene expression …

Background: Conversion of cardiac stromal cells into myofibroblasts is typically associated
with hypoxia conditions, metabolic insults, and/or inflammation, all of which are predisposing …

Fibrosis results from defective wound healing processes often seen after chronic injury
and/or inflammation in a range of organs. Progressive fibrotic events may lead to permanent …

With cardiovascular disease (CVD) being a primary source of global morbidity and mortality,
it is crucial that we understand the molecular pathophysiological mechanisms at play …

Cardiovascular diseases and specifically heart failure (HF) impact global health and impose
a significant economic burden on society. Despite current advances in standard of care, the …

Cardiac diseases, such as myocardial infarction and heart failure, have become a major
clinical problem globally. The accumulating data demonstrate that bioactive compounds with …

Innate immune cells are responsible for eliminating foreign infectious agents and cellular
debris, and their ability to perceive, respond to, and integrate biochemical and mechanical …

Background Excessive myocardial fibrosis is the pathological basis of heart failure following
myocardial infarction (MI). Although calycosin improves cardiac function, its effect on cardiac …