Inhalable nanoparticle-based dry powder formulations for respiratory diseases: challenges and strategies for translational research

HW Chan, S Chow, X Zhang, Y Zhao, HHY Tong… - AAPS …, 2023 - Springer
The emergence of novel respiratory infections (eg, COVID-19) and expeditious development
of nanoparticle-based COVID-19 vaccines have recently reignited considerable interest in …

Role of particle size in translational research of nanomedicines for successful drug delivery: Discrepancies and inadequacies

HW Chan, S Chow, X Zhang, PCL Kwok… - Journal of Pharmaceutical …, 2023 - Elsevier
Despite significant research progress in substantiating the therapeutic merits of
nanomedicines and the emergence of sophisticated nanotechnologies, the translation of this …

Intracerebral fate of organic and inorganic nanoparticles is dependent on microglial extracellular vesicle function

J Gao, Q Song, X Gu, G Jiang, J Huang, Y Tang… - Nature …, 2024 - nature.com
Nanoparticles (NPs) represent an important advance for delivering diagnostic and
therapeutic agents across the blood–brain barrier. However, NP clearance is critical for …

Integrated continuous manufacturing of inhalable remdesivir nanoagglomerate dry powders: Design, optimization and therapeutic potential for respiratory viral …

HW Chan, HW Lee, S Chow, DCL Lam… - International Journal of …, 2023 - Elsevier
While inhalable nanoparticle-based dry powders have demonstrated promising potential as
next-generation respiratory medicines, erratic particle redispersibility and poor …

Inhalable dry powder nano-formulations: advancing lung disease therapy-a review

F Naureen, Y Shah, M Rehman, P Chaubey… - Frontiers in …, 2024 - frontiersin.org
The exposure of human beings to various respiratory diseases has sparked an interest
among scientists to propose and promote inhalable nanoparticle-based pharmaceutical …

Physicochemical profiling of nanomedicines using centrifugal field flow fractionation

E Yamamoto, M Nikko, M Miyatsuji, D Ando… - International Journal of …, 2024 - Elsevier
Nanomedicines comprise multiple components, and particle density is considered an
important property that regulates the biodistribution of administered nanomedicines. The …

Biological Synthesis of Cerium Oxide Nanoparticles Using Funnel Extract: Characterization and Evaluation of Its Angiogenesis and Cytotoxicity Properties Against …

SJS Al Khafaji, M Ghobeh, M Mashergi, A Es-haghi - BioNanoScience, 2024 - Springer
The present study aims to characterize bio-synthesized cerium oxide nanoparticles (CNPs).
Various analytical techniques, including Fourier transform infrared spectroscopy (FTIR) …

[HTML][HTML] Navigating translational research in nanomedicine: A strategic guide to formulation and manufacturing

X Zhang, HW Chan, Z Shao, Q Wang, S Chow… - International Journal of …, 2025 - Elsevier
Over the past two decades, extensive research has focused on both the fundamental and
applied aspects of nanomedicine, driven by the compelling advantages that nanoparticles …

Inhalable paclitaxel nanoagglomerate dry powders for lung cancer chemotherapy: Design of experiments-guided development, characterization and in vitro …

HW Chan, X Zhang, S Chow, DCL Lam… - International Journal of …, 2024 - Elsevier
Conventional intravenous chemotherapy for lung cancer frequently results in inefficient drug
penetration into primary lung tumors and severe systemic toxicities. This study reports the …

Rational development of fingolimod nano-embedded microparticles as nose-to-brain neuroprotective therapy for ischemic stroke

X Zhang, G Su, Z Shao, HW Chan, S Li, S Chow… - Drug Delivery and …, 2024 - Springer
Ischemic stroke is one of the major diseases causing varying degrees of dysfunction and
disability worldwide. The current management of ischemic stroke poses significant …