Spike timing-dependent plasticity (STDP) is a bidirectional form of synaptic plasticity
discovered about 30 years ago and based on the relative timing of pre-and post-synaptic …

Half a century since their discovery by Llinás and colleagues, dendritic spikes have been
observed in various neurons in different brain regions, from the neocortex and cerebellum to …

Neuronal activity plays a critical role in the maturation of circuits that propagate sensory
information into the brain. How widely does early activity regulate circuit maturation across …

The olfactory tubercle (OT), which is a component of the olfactory cortex and ventral striatum,
has functional domains that play a role in odor-guided motivated behaviors. Learning odor …

Volatile chemicals in the environment provide ethologically important information to many
animals. However, how animals learn to use this information is only beginning to be …

Centrifugal projections in the olfactory system are critical to both olfactory processing and
behavior. The olfactory bulb (OB), the first relay station in odor processing, receives a …

The olfactory system is an ideal and tractable system for exploring how the brain transforms
sensory inputs into behaviour. The basic tasks of any olfactory system include odour …

Feedforward inhibitory circuits are key contributors to the complex interplay between
excitation and inhibition in the brain. Little is known about the function of feedforward …

Long-term synaptic plasticity is mediated via cytosolic calcium concentrations ([Ca2+]).
Using a synaptic model that implements calcium-based long-term plasticity via two sources …

Cognitive dysfunction stands as a prevalent and consequential non-motor manifestation in
Parkinson's disease (PD). Although dysfunction of the olfactory system has been recognized …