The venom of the marine predatory cone snails (genus Conus) has evolved for prey capture
and defense, providing the basis for survival and rapid diversification of the now estimated …

Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than
700 species, have always been one of the focuses for new drug discovery. These venomous …

The treatment of some high-incidence human diseases is based on therapeutic cell killing.
In cancer this is mainly achieved by chemical drugs that are systemically administered to …

Snake venom three-finger α-neurotoxins (α-3FNTx) act on postsynaptic nicotinic
acetylcholine receptors (nAChRs) at the neuromuscular junction (NMJ) to produce skeletal …

Voltage‐gated sodium channels (NaV channels) are essential for the initiation and
propagation of action potentials that critically influence our ability to respond to a diverse …

Transcriptome-based exon capture methods provide an approach to recover several
hundred markers from genomic DNA, allowing for robust phylogenetic estimation at deep …

Venom composition varies across snakes from all taxonomic levels and is influenced by the
snakes' age, habitat, diet, and sexual dimorphism. The present study reports the first in …

The vast diversity of neuronal nicotinic acetylcholine subunits expressed in the central and
peripheral nervous systems, as well as in non-neuronal tissues, constitutes a formidable …

G protein-coupled receptors (GPCRs) represent important drug targets, as they regulate
pivotal physiological processes and they have proved to be readily druggable. Natural …

Disulfide bonds typically introduce conformational constraints into peptides and proteins,
conferring improved biopharmaceutical properties and greater therapeutic potential. In our …