Mitochondria are essential for the viability of eukaryotic cells as they perform crucial
functions in bioenergetics, metabolism and signalling and have been associated with …

Mitochondria are central to energy production, metabolism and signaling, and apoptosis. To
make new mitochondria from preexisting mitochondria, the cell needs to import …

The biogenesis of mitochondria depends on the import of hundreds of preproteins. N-
terminal matrix-targeting signals (MTSs) direct preproteins to the surface receptors Tom20 …

While targeting of proteins synthesized in the cytosol to any organelle is complex,
mitochondria present the most challenging of destinations. First, import of nuclear-encoded …

Eukaryotes organize cellular contents into membrane-bound organelles and membrane-
less condensates, for example, protein aggregates. An unsolved question is why the …

Most mitochondrial proteins are synthesized as precursors in the cytosol and post-
translationally transported into mitochondria. The mitochondrial surface protein Tom70 acts …

Tom70 is a versatile adaptor protein of 70 kDa anchored in the outer membrane of
mitochondria in metazoa, fungi and amoeba. The tertiary structure was resolved for the …

Mitochondria are essential organelles of eukaryotic cells. They consist of hundreds of
different proteins that exhibit crucial activities in respiration, catabolic metabolism and the …

Mitochondrial biogenesis has two major steps: the transcriptional activation of nuclear
genome-encoded mitochondrial proteins and the import of nascent mitochondrial proteins …

Mitochondria are essential organelles for cellular energy production, metabolic
homeostasis, calcium homeostasis, cell proliferation, and apoptosis. About 99% of …