Adenoviral vectors as vaccines for emerging avian influenza viruses

LJ Kerstetter, S Buckley, CM Bliss… - Frontiers in …, 2021 - frontiersin.org
It is evident that the emergence of infectious diseases, which have the potential for spillover
from animal reservoirs, pose an ongoing threat to global health. Zoonotic transmission …

More than just gene therapy vectors: Lentiviral vector pseudotypes for serological investigation

K Toon, EM Bentley, G Mattiuzzo - Viruses, 2021 - mdpi.com
Serological assays detecting neutralising antibodies are important for determining the
immune responses following infection or vaccination and are also often considered a …

[PDF][PDF] A pan‐genotype hepatitis C virus viral vector vaccine generates T cells and neutralizing antibodies in mice

T Donnison, J McGregor, S Chinnakannan… - …, 2022 - Wiley Online Library
Background and Aims A prophylactic vaccine targeting multiple HCV genotypes (gt) is
urgently required to meet World Health Organization elimination targets. Neutralizing …

The design and development of a multi-HBV antigen encoded in chimpanzee adenoviral and modified vaccinia Ankara viral vectors; a novel therapeutic vaccine …

SK Chinnakannan, TN Cargill, TA Donnison, MA Ansari… - Vaccines, 2020 - mdpi.com
Chronic hepatitis B virus (HBV) infection affects 257 million people globally. Current
therapies suppress HBV but viral rebound occurs on cessation of therapy; novel therapeutic …

[HTML][HTML] Vaccination with viral vectors expressing NP, M1 and chimeric hemagglutinin induces broad protection against influenza virus challenge in mice

GA Arunkumar, M McMahon, V Pavot, M Aramouni… - Vaccine, 2019 - Elsevier
Seasonal influenza virus infections cause significant morbidity and mortality every year.
Annual influenza virus vaccines are effective but only when well matched with circulating …

Integrase defective lentiviral vector as a vaccine platform for delivering influenza antigens

A Gallinaro, M Borghi, R Bona, F Grasso… - Frontiers in …, 2018 - frontiersin.org
Viral vectors represent an attractive technology for vaccine delivery. We exploited the
integrase defective lentiviral vector (IDLV) as a platform for delivering relevant antigens …

Heterologous combination of ChAdOx1 and MVA vectors expressing protein NS1 as vaccination strategy to induce durable and cross-protective CD8+ T cell immunity …

S Utrilla-Trigo, L Jiménez-Cabello, R Alonso-Ravelo… - Vaccines, 2020 - mdpi.com
The sequence of non-structural protein NS1 of bluetongue virus (BTV), which contains
immunodominant CD8+ T cell epitopes, is highly conserved among BTV serotypes, and has …

Potent immunogenicity and protective efficacy of a multi-pathogen vaccination targeting Ebola, Sudan, Marburg and Lassa viruse

A Flaxman, S Sebastian, S Appelberg, KM Cha… - PLoS …, 2024 - journals.plos.org
Viral haemorrhagic fevers (VHF) pose a significant threat to human health. In recent years,
VHF outbreaks caused by Ebola, Marburg and Lassa viruses have caused substantial …

Universal influenza virus vaccines: what needs to happen next?

C Trucchi, C Paganino, D Amicizia, A Orsi… - Expert Opinion on …, 2019 - Taylor & Francis
Introduction: Influenza occurs worldwide and causes significant disease burden in terms of
morbidity, associated complications, hospitalizations, and deaths. Vaccination constitutes …

The Combined Expression of the Nonstructural Protein NS1 and the N-Terminal Half of NS2 (NS21-180) by ChAdOx1 and MVA Confers Protection against Clinical …

S Utrilla-Trigo, L Jiménez-Cabello… - Journal of …, 2022 - Am Soc Microbiol
Bluetongue, caused by bluetongue virus (BTV), is a widespread arthropod-borne disease of
ruminants that entails a recurrent threat to the primary sector of developed and developing …