With recent rapid advancement of methodological tools, mechanistic understanding of
biological processes leading to carcinogenesis is expanding. New approach methodologies …

In the past 10 years, the public, private, and non-profit sectors have found agreement that
hazard identification and risk assessment should capitalize on the explosion of knowledge …

Cisplatin (DDP) resistance is a bottleneck in the treatment of head and neck cancer (HNC),
leading to poor prognosis. Fisetin, a dietary flavonoid, has low toxicity and high antitumor …

Metal-on-metal (MoM) hip implants made of cobalt chromium (CoCr) alloy have shown early
failure compared with other bearing materials. A consequence of the abnormal wear …

There is increasing interest in using modern 'omics technologies, such as whole
transcriptome sequencing, to inform decisions about human health safety and chemical …

Toxicological risk assessment is essential in the evaluation and authorization of different
classes of chemical substances. Genotoxicity and mutagenicity testing are of highest priority …

In this paper, we evaluate the PPARα signaling network in rats, examining transcriptional
responses in primary hepatocytes exposed to a PPARα specific ligand, GW7647. These …

Abstract Acetamide (CAS 60-35-5) is detected in common foods. Chronic rodent bioassays
led to its classification as a group 2B possible human carcinogen due to the induction of liver …

Single, high doses of TCDD in rats caused wasting, a progressive loss of 30 to 50% body
weight and death within several weeks. To identify pathway perturbations at or near doses …

Recently, we reported an in vitro toxicogenomics comparison approach to categorize
chemical substances according to similarities in their proposed toxicological modes of …