Pathogenesis, epidemiology and control of Group A Streptococcus infection

S Brouwer, T Rivera-Hernandez, BF Curren… - Nature Reviews …, 2023 - nature.com
Abstract Streptococcus pyogenes (Group A Streptococcus; GAS) is exquisitely adapted to
the human host, resulting in asymptomatic infection, pharyngitis, pyoderma, scarlet fever or …

Disease manifestations and pathogenic mechanisms of group A Streptococcus

MJ Walker, TC Barnett, JD McArthur… - Clinical microbiology …, 2014 - Am Soc Microbiol
Streptococcus pyogenes, also known as group A Streptococcus (GAS), causes mild human
infections such as pharyngitis and impetigo and serious infections such as necrotizing …

Masquerading microbial pathogens: capsular polysaccharides mimic host-tissue molecules

BF Cress, JA Englaender, W He… - FEMS microbiology …, 2014 - academic.oup.com
The increasing prevalence of antibiotic-resistant bacteria portends an impending
postantibiotic age, characterized by diminishing efficacy of common antibiotics and routine …

Bacterial glycobiology: rhamnose-containing cell wall polysaccharides in Gram-positive bacteria

MY Mistou, IC Sutcliffe… - FEMS microbiology …, 2016 - academic.oup.com
The composition of the Gram-positive cell wall is typically described as containing
peptidoglycan, proteins and essential secondary cell wall structures called teichoic acids …

Population and whole genome sequence based characterization of invasive group A streptococci recovered in the United States during 2015

S Chochua, BJ Metcalf, Z Li, J Rivers, S Mathis… - MBio, 2017 - Am Soc Microbiol
Group A streptococci (GAS) are genetically diverse. Determination of strain features can
reveal associations with disease and resistance and assist in vaccine formulation. We …

The fall and rise of Group A Streptococcus diseases

TC Barnett, AC Bowen, JR Carapetis - Epidemiology & Infection, 2019 - cambridge.org
Streptococcus pyogenes (or Group A Streptococcus, GAS) is a Gram-positive human
pathogen responsible for a diverse array of superficial, invasive and immune-related …

A molecular trigger for intercontinental epidemics of group A Streptococcus

L Zhu, RJ Olsen, W Nasser, SB Beres… - The Journal of …, 2015 - Am Soc Clin Investig
The identification of the molecular events responsible for strain emergence, enhanced
virulence, and epidemicity has been a long-pursued goal in infectious diseases research. A …

Emergence of a New Highly Successful Acapsular Group A Streptococcus Clade of Genotype emm89 in the United Kingdom

CE Turner, J Abbott, T Lamagni, MTG Holden, S David… - MBio, 2015 - Am Soc Microbiol
ABSTRACT Group A Streptococcus (GAS) genotype emm 89 is increasingly recognized as a
leading cause of disease worldwide, yet factors that underlie the success of this emm type …

The Streptococcus pyogenes hyaluronic acid capsule promotes experimental nasal and skin infection by preventing neutrophil-mediated clearance

JR Hurst, BA Shannon, HC Craig, A Rishi… - PLoS …, 2022 - journals.plos.org
Streptococcus pyogenes is a globally prominent human-specific pathogen responsible for
an enormous burden of human illnesses, including> 600 million pharyngeal and> 100 …

Trading Capsule for Increased Cytotoxin Production: Contribution to Virulence of a Newly Emerged Clade of emm89 Streptococcus pyogenes

L Zhu, RJ Olsen, W Nasser, I de la Riva Morales… - MBio, 2015 - Am Soc Microbiol
Strains of emm89 Streptococcus pyogenes have become one of the major causes of
invasive infections worldwide in the last 10 years. We recently sequenced the genome of …