Gangliosides are carbohydrate-containing sphingolipids that are widely expressed in
normal tissues, making most subtypes unsuitable as targets for cancer therapy. However …

Natural killer (NK) cells play a major role in cancer immunotherapies that involve tumor-
antigen targeting by monoclonal antibodies (mAbs). NK cells express a variety of activating …

Immune checkpoint blockade (ICB) therapy provides remarkable clinical gains and has
been very successful in treatment of melanoma. However, only a subset of patients with …

Neuroblastoma is a solid tumour that arises from the developing sympathetic nervous
system. Over the past decade, our understanding of this disease has advanced …

We generated MHC-independent chimeric antigen receptors (CARs) directed to the GD2
antigen expressed by neuroblastoma tumor cells and treated patients with this disease. Two …

Background Preclinical and preliminary clinical data indicate that ch14. 18, a monoclonal
antibody against the tumor-associated disialoganglioside GD2, has activity against …

Neuroblastoma, an embryonal cancer of the autonomic nervous system, is the most common
cancer diagnosed during the first year of life. Although neuroblastoma accounts for …

Although significant improvements have been made in the outcomes of children with cancer,
the pace of improvement has slowed in recent years as the limits of therapy intensification …

Introduction: Current therapeutic approaches for high-risk neuroblastoma (HR-NB) include
high-dose chemotherapy, surgery and radiotherapy; interventions that are associated with …

Cancer stem cells (CSCs) are a small subpopulation of cancer cells that have increased
resistance to conventional therapies and are capable of establishing metastasis. However …