Lipids, as the basic component of cell membranes, play an important role in human health
as well as brain function. The brain is highly enriched in lipids, and disruption of lipid …

Extracellular adenine nucleotides play important roles in cell–cell communication and tissue
homeostasis. High concentrations of extracellular ATP released by dying cells are sensed …

Abstract Phosphatidylinositol (4, 5) bisphosphate (PI (4, 5) P2) has become a major focus in
biochemistry, cell biology and physiology owing to its diverse functions at the plasma …

Phospholipase C (PLC) converts phosphatidylinositol 4, 5-bisphosphate (PIP2) to inositol 1,
4, 5-trisphosphate (IP3) and diacylglycerol (DAG). DAG and IP3 each control diverse cellular …

Myo-inositol has been established as an important growth-promoting factor of mammalian
cells and animals. The role of myo-inositol as a lipotropic factor has been proven, in addition …

Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide.
To date, identification of common genetic variants influencing blood pressure has proven …

The neutral lipids diacylglycerols (DAGs) are involved in a plethora of metabolic pathways.
They function as components of cellular membranes, as building blocks for glycero …

It has long been known that endothelial Ca2+ signals drive angiogenesis by recruiting
multiple Ca2+-sensitive decoders in response to pro-angiogenic cues, such as vascular …

There are numerous studies that suggest multiple links between the cellular
phosphoinositide system and cancer. As key roles in cancer have been established for PI3K …

Pulmonary surfactant is essential for life and is composed of a complex lipoprotein-like
mixture that lines the inner surface of the lung to prevent alveolar collapse at the end of …