MPNs as inflammatory diseases: the evidence, consequences, and perspectives
HC Hasselbalch, ME Bjørn - Mediators of inflammation, 2015 - Wiley Online Library
In recent years the evidence is increasing that chronic inflammation may be an important
driving force for clonal evolution and disease progression in the Philadelphia‐negative …
driving force for clonal evolution and disease progression in the Philadelphia‐negative …
The role of reactive oxygen species in myelofibrosis and related neoplasms
ME Bjørn, HC Hasselbalch - Mediators of Inflammation, 2015 - Wiley Online Library
Reactive oxygen species (ROS) have been implicated in a wide variety of disorders ranging
between traumatic, infectious, inflammatory, and malignant diseases. ROS are involved in …
between traumatic, infectious, inflammatory, and malignant diseases. ROS are involved in …
[HTML][HTML] IGFBP-6/sonic hedgehog/TLR4 signalling axis drives bone marrow fibrotic transformation in primary myelofibrosis
Primary myelofibrosis is a Ph-negative chronic myeloproliferative neoplasm characterized
by bone marrow fibrosis and associated with the involvement of several pathways, in …
by bone marrow fibrosis and associated with the involvement of several pathways, in …
[HTML][HTML] A practical perspective of the hematologic manifestations of systemic lupus erythematosus
JC Santacruz, MJ Mantilla, I Rueda, S Pulido… - Cureus, 2022 - ncbi.nlm.nih.gov
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease with an unknown
etiology that can affect any organ or system of the human body. Hematological, renal, or …
etiology that can affect any organ or system of the human body. Hematological, renal, or …
[HTML][HTML] Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development
M Andersen, Z Sajid, RK Pedersen… - PLoS …, 2017 - journals.plos.org
The chronic Philadelphia-negative myeloproliferative neoplasms (MPNs) are acquired stem
cell neoplasms which ultimately may transform to acute myelogenous leukemia. Most …
cell neoplasms which ultimately may transform to acute myelogenous leukemia. Most …
[HTML][HTML] Revisiting circulating extracellular matrix fragments as disease markers in myelofibrosis and related neoplasms
HC Hasselbalch, P Junker, V Skov, L Kjær… - Cancers, 2023 - mdpi.com
Simple Summary MPN blood cancers are characterized by elevated blood cell counts.
Chronic inflammation drives MPNs, which after 10–30 years, may lead to bone marrow …
Chronic inflammation drives MPNs, which after 10–30 years, may lead to bone marrow …
[HTML][HTML] Cancer immune therapy for Philadelphia chromosome-negative chronic myeloproliferative neoplasms
MO Holmström, HC Hasselbalch, MH Andersen - Cancers, 2020 - mdpi.com
Philadelphia chromosome-negative chronic myeloproliferative neoplasms (MPN) are
neoplastic diseases of the hematopoietic stem cells in the bone marrow. MPN are …
neoplastic diseases of the hematopoietic stem cells in the bone marrow. MPN are …
Spontaneous T-cell responses against the immune check point programmed-death-ligand 1 (PD-L1) in patients with chronic myeloproliferative neoplasms correlate …
MO Holmström, CH Riley, V Skov, IM Svane… - …, 2018 - Taylor & Francis
ABSTRACT The Chronic Myeloproliferative Neoplasms (MPN) are cancers characterized by
hyperinflammation and immune deregulation. Concurrently, the expression of the immune …
hyperinflammation and immune deregulation. Concurrently, the expression of the immune …
[HTML][HTML] Impact of anti-endothelial cell antibodies (AECAs) in patients with polycythemia vera and thrombosis
R Cacciola, E Gentilini Cacciola, V Vecchio, E Cacciola - Diagnostics, 2022 - mdpi.com
Polycythemia vera (PV) causes thrombosis. Erythrocytosis and cell adhesiveness are
responsible for thrombosis. JAK2V617F causes inflammation and autoimmunity; however …
responsible for thrombosis. JAK2V617F causes inflammation and autoimmunity; however …
The role of YKL-40 in a cancerous process
A Rusak, K Jabłońska, P Dzięgiel - Advances in Hygiene and Experimental …, 2016 - phmd.pl
YKL-40 is a secretory protein secreted among others by tumor cells and tumor-associated
macrophages. Due to the structural homology this protein was classified to chitinases family …
macrophages. Due to the structural homology this protein was classified to chitinases family …