Spatially resolved mass spectrometry at the single cell: recent innovations in proteomics and metabolomics
MJ Taylor, JK Lukowski… - Journal of the American …, 2021 - ACS Publications
Biological systems are composed of heterogeneous populations of cells that
intercommunicate to form a functional living tissue. Biological function varies greatly across …
intercommunicate to form a functional living tissue. Biological function varies greatly across …
Ambient ionization mass spectrometry: recent developments and applications
The early 2000s brought a new age in the field of mass spectrometry (MS) with the
introduction of ambient ionization MS techniques. As defined by one of its early visionaries …
introduction of ambient ionization MS techniques. As defined by one of its early visionaries …
High spatial resolution imaging of biological tissues using nanospray desorption electrospray ionization mass spectrometry
Mass spectrometry imaging (MSI) enables label-free spatial mapping of hundreds of
biomolecules in tissue sections. This capability provides valuable information on tissue …
biomolecules in tissue sections. This capability provides valuable information on tissue …
Native mass spectrometry imaging of proteins and protein complexes by nano-DESI
Previously, we have demonstrated native mass spectrometry imaging (native MSI) in which
the spatial distribution of proteins maintained in their native-like, folded conformations was …
the spatial distribution of proteins maintained in their native-like, folded conformations was …
Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection
TWF Lung, D Charytonowicz, KG Beaumont, SS Shah… - Cell metabolism, 2022 - cell.com
K. pneumoniae sequence type 258 (Kp ST258) is a major cause of healthcare-associated
pneumonia. However, it remains unclear how it causes protracted courses of infection in …
pneumonia. However, it remains unclear how it causes protracted courses of infection in …
Imaging and analysis of isomeric unsaturated lipids through online photochemical derivatization of carbon–carbon double bonds
Unraveling the complexity of the lipidome requires the development of novel approaches for
the structural characterization of lipid species with isomer‐level discrimination. Herein, we …
the structural characterization of lipid species with isomer‐level discrimination. Herein, we …
On‐tissue chemical derivatization in mass spectrometry imaging
C Harkin, KW Smith, FL Cruickshank… - Mass spectrometry …, 2022 - Wiley Online Library
Mass spectrometry imaging (MSI) combines molecular and spatial information in a valuable
tool for a wide range of applications. Matrix‐assisted laser desorption/ionization (MALDI) is …
tool for a wide range of applications. Matrix‐assisted laser desorption/ionization (MALDI) is …
High-resolution imaging and identification of biomolecules using Nano-DESI coupled to ion mobility spectrometry
Simultaneous spatial localization and structural characterization of molecules in complex
biological samples currently represents an analytical challenge for mass spectrometry …
biological samples currently represents an analytical challenge for mass spectrometry …
What are we imaging? Software tools and experimental strategies for annotation and identification of small molecules in mass spectrometry imaging
G Baquer, L Sementé, T Mahamdi… - Mass Spectrometry …, 2023 - Wiley Online Library
Mass spectrometry imaging (MSI) has become a widespread analytical technique to perform
nonlabeled spatial molecular identification. The Achilles' heel of MSI is the annotation and …
nonlabeled spatial molecular identification. The Achilles' heel of MSI is the annotation and …
Native ambient mass spectrometry imaging of ligand-bound and metal-bound proteins in rat brain
Label-free spatial mapping of the noncovalent interactions of proteins in their tissue
environment has the potential to revolutionize life sciences research by providing …
environment has the potential to revolutionize life sciences research by providing …