Mechanism of action of ribosomally synthesized and post-translationally modified peptides

C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Marine natural products

AR Carroll, BR Copp, RA Davis, RA Keyzers… - Natural Product …, 2020 - pubs.rsc.org
This review covers the literature published between January and December in 2018 for
marine natural products (MNPs), with 717 citations (706 for the period January to December …

Strategies to access biosynthetic novelty in bacterial genomes for drug discovery

F Hemmerling, J Piel - Nature Reviews Drug Discovery, 2022 - nature.com
Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …

PARP Inhibitors: Extending Benefit Beyond BRCA-Mutant Cancers

PG Pilié, CM Gay, LA Byers, MJ O'Connor… - Clinical Cancer Research, 2019 - AACR
A mounting body of evidence now indicates that PARP inhibitors have the potential to be
used as a foundation for both monotherapy and combination strategies across a wide …

Heterologous expression of bacterial natural product biosynthetic pathways

L Huo, JJ Hug, C Fu, X Bian, Y Zhang… - Natural product reports, 2019 - pubs.rsc.org
Covering: 2013 to June 2018 Heterologous expression of natural product biosynthetic
pathways is of increasing interest in microbial biotechnology, drug discovery and …

From marine origin to therapeutics: The antitumor potential of marine algae-derived compounds

C Alves, J Silva, S Pinteus, H Gaspar… - Frontiers in …, 2018 - frontiersin.org
Marine environment has demonstrated to be an interesting source of compounds with
uncommon and unique chemical features on which the molecular modeling and chemical …

Ancient plant-like terpene biosynthesis in corals

I Burkhardt, T de Rond, PYT Chen, BS Moore - Nature chemical biology, 2022 - nature.com
Octocorals are major contributors of terpenoid chemical diversity in the ocean. Natural
products from other sessile marine animals are primarily biosynthesized by symbiotic …

Concepts and methods to access novel antibiotics from actinomycetes

JJ Hug, CD Bader, M Remškar, K Cirnski, R Müller - Antibiotics, 2018 - mdpi.com
Actinomycetes have been proven to be an excellent source of secondary metabolites for
more than half a century. Exhibiting various bioactivities, they provide valuable approved …

A natural product chemist's guide to unlocking silent biosynthetic gene clusters

BC Covington, F Xu… - Annual review of …, 2021 - annualreviews.org
Microbial natural products have provided an important source of therapeutic leads and
motivated research and innovation in diverse scientific disciplines. In recent years, it has …