Mechanism of action of ribosomally synthesized and post-translationally modified peptides
C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …
product class that has undergone significant expansion due to the rapid growth in genome …
New developments in RiPP discovery, enzymology and engineering
M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …
Marine natural products
This review covers the literature published between January and December in 2018 for
marine natural products (MNPs), with 717 citations (706 for the period January to December …
marine natural products (MNPs), with 717 citations (706 for the period January to December …
Strategies to access biosynthetic novelty in bacterial genomes for drug discovery
F Hemmerling, J Piel - Nature Reviews Drug Discovery, 2022 - nature.com
Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
PARP Inhibitors: Extending Benefit Beyond BRCA-Mutant Cancers
A mounting body of evidence now indicates that PARP inhibitors have the potential to be
used as a foundation for both monotherapy and combination strategies across a wide …
used as a foundation for both monotherapy and combination strategies across a wide …
Heterologous expression of bacterial natural product biosynthetic pathways
Covering: 2013 to June 2018 Heterologous expression of natural product biosynthetic
pathways is of increasing interest in microbial biotechnology, drug discovery and …
pathways is of increasing interest in microbial biotechnology, drug discovery and …
From marine origin to therapeutics: The antitumor potential of marine algae-derived compounds
Marine environment has demonstrated to be an interesting source of compounds with
uncommon and unique chemical features on which the molecular modeling and chemical …
uncommon and unique chemical features on which the molecular modeling and chemical …
Ancient plant-like terpene biosynthesis in corals
Octocorals are major contributors of terpenoid chemical diversity in the ocean. Natural
products from other sessile marine animals are primarily biosynthesized by symbiotic …
products from other sessile marine animals are primarily biosynthesized by symbiotic …
Concepts and methods to access novel antibiotics from actinomycetes
Actinomycetes have been proven to be an excellent source of secondary metabolites for
more than half a century. Exhibiting various bioactivities, they provide valuable approved …
more than half a century. Exhibiting various bioactivities, they provide valuable approved …
A natural product chemist's guide to unlocking silent biosynthetic gene clusters
BC Covington, F Xu… - Annual review of …, 2021 - annualreviews.org
Microbial natural products have provided an important source of therapeutic leads and
motivated research and innovation in diverse scientific disciplines. In recent years, it has …
motivated research and innovation in diverse scientific disciplines. In recent years, it has …