Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
characterized by focal demyelination patches associated with inflammatory infiltrates …

We surveyed the T cell receptor repertoire in three separate compartments (brain,
cerebrospinal fluid, and blood) of two multiple sclerosis patients who initially had diagnostic …

Natalizumab (NTZ), a monoclonal antibody recognizing the alpha4 integrin chain, has been
approved for the treatment of active multiple sclerosis, but expose to the onset of a rare side …

Objective In multiple sclerosis (MS), central nervous system (CNS), cerebrospinal fluid
(CSF), and blood display TCR clonal expansions of CD 8+ T cells. These clones have been …

Negative selection of self-reactive T-cells during thymic development, along with activation-
induced cell death in peripheral lymphocytes, is designed to limit the expansion and …

The antigen-specific activation of pathogenic T cells is considered essential in the initiation
and maintenance of multiple sclerosis (MS). The site of activation, the differential …

Multiple sclerosis is an inflammatory demyelinating disease of the CNS associated with T
cells autoreactive for myelin components. In this study, we analysed the T‐cell receptor …

Objective: To assess changes in the T-cell receptor (TCR) repertoire in peripheral venous
blood and CSF of patients with multiple sclerosis (MS) treated with natalizumab and the …

T cells recognizing self or microbial antigens may trigger or reactivate immune‐mediated
diseases. Monitoring the frequency of specific T cell clonotypes to assess a possible link …

Objective Analysis of the T‐cell receptor (TCR) repertoire in the cerebrospinal fluid (CSF) of
patients with multiple sclerosis (MS) can reveal antigen‐specific immune responses …