Early life adversities and lifelong health outcomes: A review of the literature on large, social, long-lived nonhuman mammals
AM Dettmer, DE Chusyd - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
Social nonhuman animals are powerful models for studying underlying factors related to
lifelong health outcomes following early life adversities (ELAs). ELAs can be linked to …
lifelong health outcomes following early life adversities (ELAs). ELAs can be linked to …
[HTML][HTML] The applied implications of epigenetics in anxiety, affective and stress-related disorders-A review and synthesis on psychosocial stress, psychotherapy and …
MA Schiele, MG Gottschalk, K Domschke - Clinical psychology review, 2020 - Elsevier
Mental disorders are highly complex and multifactorial in origin, comprising an elaborate
interplay of genetic and environmental factors. Epigenetic mechanisms such as DNA …
interplay of genetic and environmental factors. Epigenetic mechanisms such as DNA …
Sensitive periods for the effect of childhood adversity on DNA methylation: results from a prospective, longitudinal study
Background Exposure to early-life adversity is known to predict DNA methylation (DNAm)
patterns that may be related to psychiatric risk. However, few studies have investigated …
patterns that may be related to psychiatric risk. However, few studies have investigated …
Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children
Objectives Exposure to adversity has been linked to accelerated biological aging, which in
turn has been shown to predict numerous physical and mental health problems. In recent …
turn has been shown to predict numerous physical and mental health problems. In recent …
[HTML][HTML] Effects of early life stress on brain cytokines: A systematic review and meta-analysis of rodent studies
Exposure to early life stress (ELS) may lead to long-lasting neurobiological and behavioral
impairments. Alterations in the immune system and neuroinflammatory state induced by ELS …
impairments. Alterations in the immune system and neuroinflammatory state induced by ELS …
The rhesus macaque as a success story of the Anthropocene
Of all the non-human primate species studied by researchers, the rhesus macaque (Macaca
mulatta) is likely the most widely used across biological disciplines. Rhesus macaques have …
mulatta) is likely the most widely used across biological disciplines. Rhesus macaques have …
The epigenetics of perinatal stress
M Szyf - Dialogues in clinical neuroscience, 2019 - Taylor & Francis
Early life adversity is associated with long-term effects on physical and mental health later in
life, but the mechanisms are yet unclear. Epigenetic mechanisms program cell-type-specific …
life, but the mechanisms are yet unclear. Epigenetic mechanisms program cell-type-specific …
Epigenetics applied to psychiatry: clinical opportunities and future challenges
L Kular, S Kular - Psychiatry and clinical neurosciences, 2018 - Wiley Online Library
Psychiatric disorders are clinically heterogeneous and debilitating chronic diseases
resulting from a complex interplay between gene variants and environmental factors …
resulting from a complex interplay between gene variants and environmental factors …
Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth
Background A recent study has shown that it is possible to accurately estimate gestational
age (GA) at birth from the DNA methylation (DNAm) of fetal umbilical cord blood/newborn …
age (GA) at birth from the DNA methylation (DNAm) of fetal umbilical cord blood/newborn …
Genome-wide signatures of early-life stress: influence of sex
Both history of early-life stress (ELS) and female sex are associated with increased risk for
depression. The complexity of how ELS interacts with brain development and sex to impart …
depression. The complexity of how ELS interacts with brain development and sex to impart …