The rapid growth of biotherapeutic industry, with more and more complex molecules
entering the market, forces the need for advanced analytical platforms that can quickly and …

The growing need for biologics to be administered subcutaneously and ocularly, coupled
with certain indications requiring high doses, has resulted in an increase in drug substance …

The multi-attribute method (MAM), a liquid chromatography-mass spectrometry (LC-MS)-
based peptide mapping method, has gained increased interest and applications in the …

In the quest to market increasingly safer and more potent biotherapeutic proteins, the
concept of the multi-attribute method (MAM) has emerged from biopharmaceutical …

Multi-attribute methods employing mass spectrometry are applied throughout the
biopharmaceutical industry for product and process characterization purposes but are not …

Highlights•Highlight CMC strategies to address the increasing rAAV vector demand.•Outline
solutions in the areas of cell line development and upstream processing to increase AAV …

The mass spectrometry based multi-attribute method (MAM) has gained popularity in the
field of biopharmaceutical analysis as it promises a single method for comprehensive …

The growing complexity of novel biopharmaceutical formats, such as Fc-fusion proteins, in
increasingly competitive environment has highlighted the need of high-throughput analytical …

The use of multi-attribute method (MAM) for identity and purity testing of biopharmaceuticals
offers the ability to complement and replace multiple conventional analytical technologies …

The biomanufacturing industry has experienced significant transformations in the past 10
years, driven by changing industry trends and rapidly maturing new technologies. However …