Thiazole: A versatile standalone moiety contributing to the development of various drugs and biologically active agents

MF Arshad, A Alam, AA Alshammari, MB Alhazza… - Molecules, 2022 - mdpi.com
For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …

Thiazoles, their benzofused systems, and thiazolidinone derivatives: versatile and promising tools to combat antibiotic resistance

S Cascioferro, B Parrino, D Carbone… - Journal of medicinal …, 2020 - ACS Publications
Thiazoles, their benzofused systems, and thiazolidinone derivatives are widely recognized
as nuclei of great value for obtaining molecules with various biological activities, including …

Theoretical investigations on the HOMO–LUMO gap and global reactivity descriptor studies, natural bond orbital, and nucleus-independent chemical shifts analyses of 3-phenylbenzo[d] …

M Miar, A Shiroudi, K Pourshamsian… - Journal of Chemical …, 2021 - journals.sagepub.com
Natural bond orbital analysis, salvation, and substituent effects of electron-releasing (–CH3,–
OH) and electron-withdrawing (–Cl,–NO2,–CF3) groups at para positions on the molecular …

Thiazolidin-4-ones as potential antimicrobial agents: Experimental and in silico evaluation

C Tratrat, A Petrou, A Geronikaki, M Ivanov, M Kostić… - Molecules, 2022 - mdpi.com
Herein, we report computational and experimental evaluations of the antimicrobial activity of
twenty one 2, 3-diaryl-thiazolidin-4-ones. All synthesized compounds exhibited an …

Therapeutic advancement of benzothiazole derivatives in the last decennial period

S Tariq, P Kamboj, M Amir - Archiv der Pharmazie, 2019 - Wiley Online Library
Benzothiazole, a fused heterocyclic moiety, has attracted synthetic and medicinal chemists
for good reasons. It is a valuable scaffold that possesses diverse biological activities, such …

New vinyl-1, 2, 4-triazole derivatives as antimicrobial agents: Synthesis, biological evaluation and molecular docking studies

E Stingaci, M Zveaghinteva, S Pogrebnoi… - Bioorganic & Medicinal …, 2020 - Elsevier
Triazole is a very important scaffold in medicinal chemistry due to the wide spectrum of
biological activities and mainly antifungal activity of 1, 2, 4-triazole derivatives. The main …

5-Adamantan thiadiazole-based thiazolidinones as antimicrobial agents. Design, synthesis, molecular docking and evaluation

M Fesatidou, P Zagaliotis, C Camoutsis… - Bioorganic & Medicinal …, 2018 - Elsevier
In continuation of our efforts to develop new compounds with antimicrobial properties we
describe design, synthesis, molecular docking study and evaluation of antimicrobial activity …

Current perspective of synthesis of medicinally relevant benzothiazole based molecules: Potential for antimicrobial and anti-inflammatory activities

K Gupta, AK Sirbaiya, V Kumar… - Mini Reviews in …, 2022 - ingentaconnect.com
The therapeutic potential of the majority of the marketed drugs is due to the presence of a
heterocyclic nucleus, which constitutes a huge role in the field of medicinal chemistry. These …

Recent insights into antibacterial potential of benzothiazole derivatives

P Kashyap, S Verma, P Gupta, R Narang, S Lal… - Medicinal Chemistry …, 2023 - Springer
Antimicrobial resistance (AMR) is a worldwide concern among infectious diseases due to
increased mortality, morbidity and treatment cost. According to WHO 2019 report, among the …

Synthesis, in‐vitro and in‐silico study of novel thiazoles as potent antibacterial agents and MurB inhibitors

SMH Sanad, AAM Ahmed, AEM Mekky - Archiv der Pharmazie, 2020 - Wiley Online Library
Efficient procedures are herein reported for the synthesis of novel hybrid thiazoles via a one‐
pot three‐component protocol. The protocol involves the reaction of novel aldehyde …