Atherosclerosis: current pathogenesis and therapeutic options

C Weber, H Noels - Nature medicine, 2011 - nature.com
Coronary artery disease (CAD) arising from atherosclerosis is a leading cause of death and
morbidity worldwide. The underlying pathogenesis involves an imbalanced lipid metabolism …

Molecular biology of atherosclerosis

PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins

PM Brunner, M Suárez-Fariñas, H He, K Malik… - Scientific reports, 2017 - nature.com
Beyond classic “allergic”/atopic comorbidities, atopic dermatitis (AD) emerges as systemic
disease with increased cardiovascular risk. To better define serum inflammatory and …

Inflammation, immunity, and hypertension

DG Harrison, TJ Guzik, HE Lob, MS Madhur… - …, 2011 - Am Heart Assoc
Aprominent pathology textbook used in the United States includes an image illustrating the
renal histopathology caused by malignant hypertension. The legend describes striking …

eNOS uncoupling in cardiovascular diseases-the role of oxidative stress and inflammation

S Karbach, P Wenzel, A Waisman… - Current …, 2014 - ingentaconnect.com
Many cardiovascular diseases and drug-induced complications are associated with-or even
based on-an imbalance between the formation of reactive oxygen and nitrogen species …

The emerging role of Th1 cells in atherosclerosis and its implications for therapy

J Chen, X Xiang, L Nie, X Guo, F Zhang… - Frontiers in …, 2023 - frontiersin.org
Atherosclerosis is a chronic progressive inflammatory disease of the large and medium-
sized artery walls. The molecular mechanisms regulating the onset and progression of …

Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension

A Vinh, W Chen, Y Blinder, D Weiss, WR Taylor… - Circulation, 2010 - Am Heart Assoc
Background—The pathogenesis of hypertension remains poorly understood, and treatment
is often unsuccessful. Recent evidence suggests that the adaptive immune response plays …

Adaptive immunity and atherosclerosis

J Andersson, P Libby, GK Hansson - Clinical immunology, 2010 - Elsevier
Atherosclerosis involves the formation of inflammatory arterial lesions and is one of the most
common causes of death globally. It has been evident for more than 20 years that adaptive …

Adaptive (T and B cells) immunity and control by dendritic cells in atherosclerosis

H Ait-Oufella, AP Sage, Z Mallat, A Tedgui - Circulation research, 2014 - Am Heart Assoc
Chronic inflammation in response to lipoprotein accumulation in the arterial wall is central in
the development of atherosclerosis. Both innate and adaptive immunity are involved in this …

Innate and adaptive immunity in atherosclerosis

RRS Packard, AH Lichtman, P Libby - Seminars in immunopathology, 2009 - Springer
Atherosclerosis, a chronic inflammatory disorder, involves both the innate and adaptive arms
of the immune response that mediate the initiation, progression, and ultimate thrombotic …