Corosolic acid and its structural analogs: A systematic review of their biological activities and underlying mechanism of action

XP Qian, XH Zhang, LN Sun, WF Xing, Y Wang… - Phytomedicine, 2021 - Elsevier
Background The corosolic acid (CA), also known as plant insulin, is a pentacyclic
triterpenoid extracted from plants such as Lagerstroemia speciosa. It has been shown to …

Traditional uses, phytochemistry, pharmacology, and toxicity of Eriobotrya japonica leaves: A summary

X Zhu, L Wang, T Zhao, Q Jiang - Journal of ethnopharmacology, 2022 - Elsevier
Abstract Ethnopharmacological relevance: Eriobotrya japonica Lindl. has been included in
“The Plant List”(http://www. theplantlist. org) and is the most widely researched species in its …

Towards cytotoxic and selective derivatives of maslinic acid

B Siewert, E Pianowski, A Obernauer, R Csuk - Bioorganic & Medicinal …, 2014 - Elsevier
Several novel esters and amides of maslinic acid were prepared. Their evaluation for
cytotoxic activity with a panel of human cancer cell lines using a sulforhodamine B (SRB) …

Corosolic acid induces non-apoptotic cell death through generation of lipid reactive oxygen species production in human renal carcinoma caki cells

SM Woo, SU Seo, K Min, SS Im, JO Nam… - International journal of …, 2018 - mdpi.com
Corosolic acid is one of the pentacyclic triterpenoids isolated from Lagerstroemia speciose
and has been reported to exhibit anti-cancer and anti-proliferative activities in various …

The anticancer potential of maslinic acid and its derivatives: A review

L Yu, X Xie, X Cao, J Chen, G Chen… - Drug Design …, 2021 - Taylor & Francis
Cancer is still an insurmountable problem for humans and critically attacking human health.
In recent years, natural products have gained increasing attention in the field of anti-tumor …

Berberine induces apoptotic cell death via activation of caspase-3 and-8 in HL-60 human leukemia cells: nuclear localization and structure–activity relationships

S Okubo, T Uto, A Goto, H Tanaka… - The American Journal …, 2017 - World Scientific
Berberine (BBR), an isoquinoline alkaloid, is a well-known bioactive compound contained in
medicinal plants used in traditional and folk medicines. In this study, we investigated the …

Bioactive phytoconstituents and their therapeutic potentials in the treatment of haematological cancers: a review

EJ Iweala, AE Oluwapelumi, OE Dania, EA Ugbogu - Life, 2023 - mdpi.com
Haematological (blood) cancers are the cancers of the blood and lymphoid forming tissues
which represents approximately 10% of all cancers. It has been reported that approximately …

2α-Hydroxyursolic acid inhibited cell proliferation and induced apoptosis in MDA-MB-231 human breast cancer cells through the p38/MAPK signal transduction …

X Jiang, T Li, RH Liu - Journal of agricultural and food chemistry, 2016 - ACS Publications
The mechanisms of action of 2α-hydroxyursolic acid in inhibiting cell proliferation and
inducing apoptosis in MDA-MB-231 human breast cancer cells were investigated. The …

Oleanolic acid loaded PEGylated PLA and PLGA nanoparticles with enhanced cytotoxic activity against cancer cells

DKW Man, L Casettari, M Cespi… - Molecular …, 2015 - ACS Publications
Oleanolic acid (OA) is a natural triterpenoid with anticancer properties, but its hydrophobic
nature and poor aqueous solubility pose challenges in pharmaceutical formulation …

Corosolic acid induces apoptotic cell death in HCT116 human colon cancer cells through a caspase-dependent pathway

B Sung, YJ Kang, DH Kim… - International …, 2014 - spandidos-publications.com
Corosolic acid (CA), a pentacyclic triterpene isolated from Lagerstroemia speciosa L.(also
known as Banaba), has been shown to exhibit anticancer properties in various cancer cell …