Machine learning methods for small data challenges in molecular science
B Dou, Z Zhu, E Merkurjev, L Ke, L Chen… - Chemical …, 2023 - ACS Publications
Small data are often used in scientific and engineering research due to the presence of
various constraints, such as time, cost, ethics, privacy, security, and technical limitations in …
various constraints, such as time, cost, ethics, privacy, security, and technical limitations in …
Protein design: From the aspect of water solubility and stability
Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …
sequence and 3D-conformation. Their manipulation represents important aspects of the …
Machine learning in enzyme engineering
Enzyme engineering plays a central role in developing efficient biocatalysts for
biotechnology, biomedicine, and life sciences. Apart from classical rational design and …
biotechnology, biomedicine, and life sciences. Apart from classical rational design and …
Protein–Sol: a web tool for predicting protein solubility from sequence
Motivation Protein solubility is an important property in industrial and therapeutic
applications. Prediction is a challenge, despite a growing understanding of the relevant …
applications. Prediction is a challenge, despite a growing understanding of the relevant …
SoluProt: prediction of soluble protein expression in Escherichia coli
J Hon, M Marusiak, T Martinek, A Kunka… - …, 2021 - academic.oup.com
Motivation Poor protein solubility hinders the production of many therapeutic and industrially
useful proteins. Experimental efforts to increase solubility are plagued by low success rates …
useful proteins. Experimental efforts to increase solubility are plagued by low success rates …
ForceGen: End-to-end de novo protein generation based on nonlinear mechanical unfolding responses using a language diffusion model
Through evolution, nature has presented a set of remarkable protein materials, including
elastins, silks, keratins and collagens with superior mechanical performances that play …
elastins, silks, keratins and collagens with superior mechanical performances that play …
Designing of a multi-epitope vaccine against the structural proteins of marburg virus exploiting the immunoinformatics approach
Marburg virus disease (MVD) caused by the Marburg virus (MARV) generally appears with
flu-like symptoms and leads to severe hemorrhagic fever. It spreads via direct contact with …
flu-like symptoms and leads to severe hemorrhagic fever. It spreads via direct contact with …
[HTML][HTML] DnaK functions as a central hub in the E. coli chaperone network
G Calloni, T Chen, SM Schermann, H Chang… - Cell reports, 2012 - cell.com
Cellular chaperone networks prevent potentially toxic protein aggregation and ensure
proteome integrity. Here, we used Escherichia coli as a model to understand the …
proteome integrity. Here, we used Escherichia coli as a model to understand the …
Distinguishing crystal-like amyloid fibrils and glass-like amorphous aggregates from their kinetics of formation
Y Yoshimura, Y Lin, H Yagi, YH Lee… - Proceedings of the …, 2012 - National Acad Sciences
Amyloid fibrils and amorphous aggregates are two types of aberrant aggregates associated
with protein misfolding diseases. Although they differ in morphology, the two forms are often …
with protein misfolding diseases. Although they differ in morphology, the two forms are often …
[HTML][HTML] Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins
The maintenance of protein solubility is a fundamental aspect of cellular homeostasis
because protein aggregation is associated with a wide variety of human diseases …
because protein aggregation is associated with a wide variety of human diseases …