Subclinical depressive symptoms are associated with increased risk of Alzheimer's disease
(AD), but the brain mechanisms underlying this relationship are still unclear. We aimed to …

Depression in later life is a significant and growing problem. Age-related differences in the
type and severity of depressive disorders continue to be questioned and necessarily …

In this study, we investigated associations between neuropsychiatric symptoms (ie, apathy,
anxiety, and depression) and cerebral atrophy, white matter lesions (WML), beta-amyloid …

Introduction Mild behavioral impairment (MBI) is characterized by the emergence of
neuropsychiatric symptoms in elderly persons. Here, we examine the associations between …

Recent data has linked anxiety and its disorders in late life to increased morbidity and
mortality, especially related to a higher cardiovascular burden and an increased cognitive …

Preventing the onset of dementia and Alzheimer's disease (AD), improving the diagnosis,
and slowing the progression of these diseases remain a challenge. The aim of this study …

Importance Depressive symptoms are prevalent among older adults and may be early
manifestations of Alzheimer disease (AD) before onset of mild cognitive impairment …

Background Higher neuroticism and lower conscientiousness are risk factors for Alzheimer's
disease and related dementias, but the underlying neuropathological correlates remain …

The development of in vivo biomarkers of Alzheimer's disease (AD) has advanced the
diagnosis of AD from a clinical syndrome to a biological construct. The preclinical stage of …

Normal brain aging is commonly associated with neural activity alteration, β-amyloid (Aβ)
deposition, and tau aggregation, driving a progressive cognitive decline in normal elderly …