Understanding the physiology of human defaecation and disorders of continence and evacuation
The act of defaecation, although a ubiquitous human experience, requires the coordinated
actions of the anorectum and colon, pelvic floor musculature, and the enteric, peripheral and …
actions of the anorectum and colon, pelvic floor musculature, and the enteric, peripheral and …
Chronic constipation
Chronic constipation is a prevalent condition that severely impacts the quality of life of those
affected. Several types of primary chronic constipation, which show substantial overlap …
affected. Several types of primary chronic constipation, which show substantial overlap …
PIEZO2 in somatosensory neurons controls gastrointestinal transit
The gastrointestinal tract is in a state of constant motion. These movements are tightly
regulated by the presence of food and help digestion by mechanically breaking down and …
regulated by the presence of food and help digestion by mechanically breaking down and …
Interstitial cells of Cajal and human colon motility in health and disease
JD Huizinga, A Hussain… - American Journal of …, 2021 - journals.physiology.org
Our understanding of human colonic motility, and autonomic reflexes that generate motor
patterns, has increased markedly through high-resolution manometry. Details of the motor …
patterns, has increased markedly through high-resolution manometry. Details of the motor …
First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques
Alterations in colonic motility are implicated in the pathophysiology of bowel disorders, but
high-resolution manometry of human colonic motor function has revealed that our …
high-resolution manometry of human colonic motor function has revealed that our …
Quantification of in vivo colonic motor patterns in healthy humans before and after a meal revealed by high‐resolution fiber‐optic manometry
PG Dinning, L Wiklendt, L Maslen… - …, 2014 - Wiley Online Library
Background Until recently, investigations of the normal patterns of motility of the healthy
human colon have been limited by the resolution of in vivo recording techniques. Methods …
human colon have been limited by the resolution of in vivo recording techniques. Methods …
Ambulatory 24-h colonic manometry in healthy humans
Our aim was to investigate motor activity of the healthy, relatively unprepared colon in the
ambulatory state. Twenty-five age-and gender-matched adults had a six-sensor solid-state …
ambulatory state. Twenty-five age-and gender-matched adults had a six-sensor solid-state …
The physiology of human defecation
S Palit, PJ Lunniss, SM Scott - Digestive diseases and sciences, 2012 - Springer
Human defecation involves integrated and coordinated sensorimotor functions, orchestrated
by central, spinal, peripheral (somatic and visceral), and enteric neural activities, acting on a …
by central, spinal, peripheral (somatic and visceral), and enteric neural activities, acting on a …
Postoperative ileus: mechanisms and future directions for research
Postoperative ileus (POI) is an abnormal pattern of gastrointestinal motility characterized by
nausea, vomiting, abdominal distension and/or delayed passage of flatus or stool, which …
nausea, vomiting, abdominal distension and/or delayed passage of flatus or stool, which …
Insights into the mechanisms underlying colonic motor patterns
In recent years there have been significant technical and methodological advances in our
ability to record the movements of the gastrointestinal tract. This has led to significant …
ability to record the movements of the gastrointestinal tract. This has led to significant …