The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator
of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous …

Biophysical cues, such as mechanical properties, play a critical role in tissue growth and
homeostasis. During organ development and tissue injury repair, compressive and tensional …

Hippo signaling is an evolutionarily conserved network that has a central role in regulating
cell proliferation and cell fate to control organ growth and regeneration. It promotes …

Hippo pathway components are structurally and functionally conserved and are notable for
their role in controlling organ size. More diverse functions of the Hippo pathway have been …

Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ)
are two homologous transcriptional coactivators that promote cell proliferation, stem cell …

To perceive their three-dimensional environment, cells and tissues must be able to sense
and interpret various physical forces like shear, tensile, and compression stress. These …

The plasma membrane allows the cell to sense and adapt to changes in the extracellular
environment by relaying external inputs via intracellular signaling networks. One central …

The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue
growth two decades ago and has been a subject extensively studied in both Drosophila and …

The Hippo pathway is important for regulating tissue homeostasis, and its dysregulation has
been implicated in human cancer. However, it is not well understood how the Hippo …

YAP1 is a transcriptional co-activator whose activity is controlled by the Hippo signaling
pathway. In addition to important functions in normal tissue homeostasis and regeneration …