Cells are equipped with numerous sensors that recognize nucleic acids, which probably
evolved for defence against viruses. Once triggered, these sensors stimulate the production …

The detection of pathogens through nucleic acid sensors is a defining principle of innate
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …

Stimulator of interferon genes (STING) links innate immunity to biological processes ranging
from antitumor immunity to microbiome homeostasis. Mechanistic understanding of the …

Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

SLE is characterised by an activation of the interferon (IFN) system, which leads to an
increased expression of IFN-regulated genes. The reasons behind the IFN signature in SLE …

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …

Axonal degeneration is a common pathological feature in many acute and chronic
neurological diseases such as spinal cord injury (SCI). SARM1 (sterile alpha and TIR motif …

Intestinal ischemia reperfusion (I/R) injury is the important pathogenesis for acute intestinal
barrier disruption. The STING signaling is associated with gut homeostasis and barrier …

Background Gut integrity is compromised in abdominal sepsis with increased cellular
apoptosis and altered barrier permeability. Intestinal epithelial cells (IEC) form a …

Stimulator of interferon genes (STING) is an important adaptor in cytosolic DNA-sensing
pathways. A recent study found that the deletion of STING ameliorated cisplatin-induced …