Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …

Neural stem cells in the adult mammalian brain are the source of new neurons that
contribute to complex sensory and cognitive functions. Most adult neural stem cells are …

Adult somatic stem cells in various organs maintain homeostatic tissue regeneration and
enhance plasticity. Since its initial discovery five decades ago, investigations of adult …

Neural stem cell (NSC)-based therapy is a promising candidate for treating
neurodegenerative diseases and the preclinical researches call an urgent need for …

Integrin-linked kinase (ILK) is a multifunctional molecular actor in cell–matrix interactions,
cell adhesion, and anchorage-dependent cell growth. It combines functions of a signal …

Tissue-specific stem cells give rise to new functional cells to maintain tissue homeostasis
and restore damaged tissue after injury. To ensure proper brain functions in the adult brain …

Radial glia-like neural stem cells (RGLs) in the dentate gyrus subregion of the hippocampus
give rise to dentate granule cells (DGCs) and astrocytes throughout life, a process referred …

Adult neurogenesis, arising from quiescent radial-glia-like neural stem cells (RGLs), occurs
throughout life in the dentate gyrus. How neural stem cells are maintained throughout …

Neuroepithelial and radial GLIA stem cells generate the majority of the cellular constituents
of the central nervous system. Following precisely timed phases of neurogenesis and …

Numerous studies demonstrated that neural stem cells and cancer stem cells (NSCs/CSCs)
share several overlapping characteristics such as self-renewal, multipotency and a …