On dihydroorotate dehydrogenases and their inhibitors and uses
H Munier-Lehmann, PO Vidalain… - Journal of medicinal …, 2013 - ACS Publications
Proper nucleosides availability is crucial for the proliferation of living entities (eukaryotic
cells, parasites, bacteria, and virus). Accordingly, the uses of inhibitors of the de novo …
cells, parasites, bacteria, and virus). Accordingly, the uses of inhibitors of the de novo …
The dihydroorotate dehydrogenases: past and present
The flavoenzyme dihydroorotate dehydrogenase catalyzes the stereoselective oxidation of
(S)-dihydroorotate to orotate in the fourth of the six conserved enzymatic reactions involved …
(S)-dihydroorotate to orotate in the fourth of the six conserved enzymatic reactions involved …
Dihydroorotate dehydrogenase inhibitors in anti-infective drug research
Pyrimidines are essential for the cell survival and proliferation of living parasitic organisms,
such as Helicobacter pylori, Plasmodium falciparum and Schistosoma mansoni, that are …
such as Helicobacter pylori, Plasmodium falciparum and Schistosoma mansoni, that are …
[HTML][HTML] Synergy and target promiscuity drive structural divergence in bacterial alkylquinolone biosynthesis
Y Wu, MR Seyedsayamdost - Cell chemical biology, 2017 - cell.com
Microbial natural products are genetically encoded by dedicated biosynthetic gene clusters
(BGCs). A given BGC usually produces a family of related compounds that share a core but …
(BGCs). A given BGC usually produces a family of related compounds that share a core but …
[HTML][HTML] Crystal structure of dihydroorotate dehydrogenase from Leishmania major
Dihydroorotate dehydrogenase (DHODH) is the fourth enzyme in the de novo pyrimidine
biosynthetic pathway and has been exploited as the target for therapy against proliferative …
biosynthetic pathway and has been exploited as the target for therapy against proliferative …
Pyrimidine pathway-dependent and-independent functions of the Toxoplasma gondii mitochondrial dihydroorotate dehydrogenase
MA Hortua Triana, D Cajiao Herrera… - Infection and …, 2016 - Am Soc Microbiol
Dihydroorotate dehydrogenase (DHODH) mediates the fourth step of de novo pyrimidine
biosynthesis and is a proven drug target for inducing immunosuppression in therapy of …
biosynthesis and is a proven drug target for inducing immunosuppression in therapy of …
[HTML][HTML] Investigating the amino acid sequences of membrane bound dihydroorotate: quinone oxidoreductases (DHOQOs): structural and functional implications
Dihydroorotate: quinone oxidoreductases (DHOQOs) are membrane bound enzymes
responsible for oxidizing dihydroorotate (DHO) to orotate with concomitant reduction of …
responsible for oxidizing dihydroorotate (DHO) to orotate with concomitant reduction of …
Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor
Mycobacterium tuberculosis (MTB) is the etiologic agent of tuberculosis (TB), an ancient
disease which causes 1.5 million deaths worldwide. Dihydroorotate dehydrogenase …
disease which causes 1.5 million deaths worldwide. Dihydroorotate dehydrogenase …
[HTML][HTML] Unveiling the membrane bound dihydroorotate: Quinone oxidoreductase from Staphylococcus aureus
Staphylococcus aureus is an opportunistic pathogen and one of the most frequent causes
for community acquired and nosocomial bacterial infections. Even so, its energy metabolism …
for community acquired and nosocomial bacterial infections. Even so, its energy metabolism …
Regulation of the pyrimidine biosynthetic pathway by lysine acetylation of E. coli OPRTase
G Lozano‐Terol, J Gallego‐Jara… - The FEBS …, 2023 - Wiley Online Library
The de novo pyrimidine biosynthesis pathway is an important route due to the relevance of
its products, its implications in health and its conservation among organisms. Here, we …
its products, its implications in health and its conservation among organisms. Here, we …