Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance
Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …
[HTML][HTML] SETDB1 in cancer: overexpression and its therapeutic implications
VJ Lazaro-Camp, K Salari, X Meng… - American journal of …, 2021 - ncbi.nlm.nih.gov
Abstract SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1, ESET,
KMT1E) is a H3K9 methyltransferase involved in gene silencing. In recent years, SETDB1 …
KMT1E) is a H3K9 methyltransferase involved in gene silencing. In recent years, SETDB1 …
[HTML][HTML] CircPTK2/PABPC1/SETDB1 axis promotes EMT-mediated tumor metastasis and gemcitabine resistance in bladder cancer
X Meng, W Xiao, J Sun, W Li, H Yuan, T Yu, X Zhang… - Cancer Letters, 2023 - Elsevier
Bladder cancer (BCa), characterized by high invasion, metastasis, recurrence, and
chemoresistance, is one of the most prevalent urologic malignant tumors. Recent studies …
chemoresistance, is one of the most prevalent urologic malignant tumors. Recent studies …
The role of regulated necrosis in endocrine diseases
The death of endocrine cells is involved in type 1 diabetes mellitus, autoimmunity,
adrenopause and hypogonadotropism. Insights from research on basic cell death have …
adrenopause and hypogonadotropism. Insights from research on basic cell death have …
The gut–immune–brain axis: an important route for neuropsychiatric morbidity in inflammatory bowel disease
Inflammatory bowel disease (IBD) comprises Crohn's disease (CD) and ulcerative colitis
(UC) and is associated with neuropsychiatric symptoms like anxiety and depression. Both …
(UC) and is associated with neuropsychiatric symptoms like anxiety and depression. Both …
COVID-19 in children: expressions of type I/II/III interferons, TRIM28, SETDB1, and endogenous retroviruses in mild and severe cases
PA Tovo, S Garazzino, V Dapra, G Pruccoli… - International journal of …, 2021 - mdpi.com
Children with the new coronavirus disease 2019 (COVID-19) have milder symptoms and a
better prognosis than adult patients. Several investigations assessed type I, II, and III …
better prognosis than adult patients. Several investigations assessed type I, II, and III …
Non-coding RNA-based regulation of inflammation
Inflammation is a multifactorial process and various biological mechanisms and pathways
participate in its development. The presence of inflammation is involved in pathogenesis of …
participate in its development. The presence of inflammation is involved in pathogenesis of …
Cryptosporidium infection of human small intestinal epithelial cells induces type III interferon and impairs infectivity of Rotavirus
Cryptosporidiosis is a major cause of severe diarrheal disease in infants from resource poor
settings. The majority of infections are caused by the human-specific pathogen C. hominis …
settings. The majority of infections are caused by the human-specific pathogen C. hominis …
Protocadherin 20 maintains intestinal barrier function to protect against Crohn's disease by targeting ATF6
S Huang, Z Xie, J Han, H Wang, G Yang, M Li, G Zhou… - Genome Biology, 2023 - Springer
Background Intestinal barrier dysfunction plays a central role in the pathological onset of
Crohn's disease. We identify the cadherin superfamily member protocadherin 20 (PCDH20) …
Crohn's disease. We identify the cadherin superfamily member protocadherin 20 (PCDH20) …
Gut microbiota: sculptors of the intestinal stem cell niche in health and inflammatory bowel disease
M Markandey, A Bajaj, NE Ilott, S Kedia, S Travis… - Gut …, 2021 - Taylor & Francis
Intestinal epithelium represents a dynamic and diverse cellular system that continuously
interacts with gut commensals and external cues. Intestinal stem cells, which lie at the heart …
interacts with gut commensals and external cues. Intestinal stem cells, which lie at the heart …