The main proteases (Mpro), also termed 3‐chymotrypsin‐like proteases (3CLpro), are a
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …

The exploration of non-toxic and cost-effective dietary components, such as epigallocatechin
3-gallate and myricetin, for health improvement and disease treatment has recently attracted …

Natural products have been a bedrock for drug discovery for decades.(−)-Epigallocatechin-3-
gallate (EGCG) is one of the widely studied natural polyphenolic compounds derived from …

The tea plant (C. sinensis) has traditionally been consumed worldwide as “tea” for its many
health benefits, with the potential for the prevention and therapy of various conditions …

Flavoalkaloids are a unique class of compounds in tea, most of which have an N-ethyl-2-
pyrrolidinone moiety substituted at the A ring of a catechin skeleton. 1-Ethyl-5-hydroxy …

Background The COVID-19 pandemic will continue to threaten our health care systems in
the next years. In addition to vaccination there is a need for effective tools for prevention and …

The COVID-19 pandemic has stimulated collaborative drug discovery efforts in academia
and the industry with the aim of developing therapies and vaccines that target SARS-CoV-2 …

Ventricular remodeling (VR) after acute myocardial infarction (AMI) is the main pathogenesis
of chronic heart failure (CHF). Kaempferol‐3‐O‐rutinoside (KR) is the flavonoid glycoside …

Highly transmissive and rapidly evolving Coronavirus disease-2019 (COVID-19), a viral
disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Direct-acting antivirals for the treatment of the COVID-19 pandemic caused by the SARS-
CoV-2 virus are needed to complement vaccination efforts. Given the ongoing emergence of …