Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …

Abstract Merlin (Moesin-ezrin-radixin-like protein, also known as schwannomin) is a tumor
suppressor protein encoded by the neurofibromatosis type 2 gene NF2. Loss of function …

Schwannomas are tumors of the peripheral nervous system, consisting of different cell types.
These include tumorigenic Schwann cells, axons, macrophages, T cells, fibroblasts, blood …

Inherited neuropathies known as Charcot-Marie-Tooth (CMT) disease are genetically
heterogeneous disorders affecting the peripheral nerves, causing significant and slowly …

Loss of the Merlin tumor suppressor and activation of the Hippo signaling pathway play
major roles in the control of cell proliferation and tumorigenesis. We have identified …

Schwannomas are predominantly benign nerve sheath neoplasms caused by Nf2 gene
inactivation. Presently, treatment options are mainly limited to surgical tumor resection due …

Schwann cells (SCs) are fundamental components of the peripheral nervous system (PNS)
of all vertebrates and play essential roles in development, maintenance, function, and …

Abstract Aims: Lack of Cu, Zn-superoxide dismutase (CuZnSOD) in homozygous knockout
mice (Sod1−/−) leads to accelerated age-related muscle loss and weakness, but specific …

Following spinal cord injury (SCI), a multitude of intrinsic and extrinsic factors adversely
affect the gene programs that govern the expression of regeneration-associated genes …

The innervation of skeletal myofibers exerts a crucial influence on the maintenance of
muscle tone and normal operation. Consequently, denervated myofibers manifest atrophy …