[HTML][HTML] Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases
Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …
Role of Merlin/NF2 inactivation in tumor biology
AM Petrilli, C Fernández-Valle - Oncogene, 2016 - nature.com
Abstract Merlin (Moesin-ezrin-radixin-like protein, also known as schwannomin) is a tumor
suppressor protein encoded by the neurofibromatosis type 2 gene NF2. Loss of function …
suppressor protein encoded by the neurofibromatosis type 2 gene NF2. Loss of function …
[HTML][HTML] Pathomechanisms in schwannoma development and progression
DL Helbing, A Schulz, H Morrison - Oncogene, 2020 - nature.com
Schwannomas are tumors of the peripheral nervous system, consisting of different cell types.
These include tumorigenic Schwann cells, axons, macrophages, T cells, fibroblasts, blood …
These include tumorigenic Schwann cells, axons, macrophages, T cells, fibroblasts, blood …
[HTML][HTML] Emerging therapies for Charcot-Marie-Tooth inherited neuropathies
M Stavrou, I Sargiannidou, E Georgiou… - International Journal of …, 2021 - mdpi.com
Inherited neuropathies known as Charcot-Marie-Tooth (CMT) disease are genetically
heterogeneous disorders affecting the peripheral nerves, causing significant and slowly …
heterogeneous disorders affecting the peripheral nerves, causing significant and slowly …
Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity
T Mindos, X Dun, K North, RDS Doddrell… - Journal of Cell …, 2017 - rupress.org
Loss of the Merlin tumor suppressor and activation of the Hippo signaling pathway play
major roles in the control of cell proliferation and tumorigenesis. We have identified …
major roles in the control of cell proliferation and tumorigenesis. We have identified …
[HTML][HTML] The importance of nerve microenvironment for schwannoma development
A Schulz, R Büttner, C Hagel, SL Baader, L Kluwe… - Acta …, 2016 - Springer
Schwannomas are predominantly benign nerve sheath neoplasms caused by Nf2 gene
inactivation. Presently, treatment options are mainly limited to surgical tumor resection due …
inactivation. Presently, treatment options are mainly limited to surgical tumor resection due …
Models and methods to study Schwann cells
S Negro, M Pirazzini, M Rigoni - Journal of Anatomy, 2022 - Wiley Online Library
Schwann cells (SCs) are fundamental components of the peripheral nervous system (PNS)
of all vertebrates and play essential roles in development, maintenance, function, and …
of all vertebrates and play essential roles in development, maintenance, function, and …
Comparison of whole body SOD1 knockout with muscle-specific SOD1 knockout mice reveals a role for nerve redox signaling in regulation of degenerative pathways …
GK Sakellariou, B McDonagh, H Porter… - Antioxidants & redox …, 2018 - liebertpub.com
Abstract Aims: Lack of Cu, Zn-superoxide dismutase (CuZnSOD) in homozygous knockout
mice (Sod1−/−) leads to accelerated age-related muscle loss and weakness, but specific …
mice (Sod1−/−) leads to accelerated age-related muscle loss and weakness, but specific …
[HTML][HTML] Regulating axonal responses to injury: the intersection between signaling pathways involved in axon myelination and the inhibition of axon regeneration
SNR Rao, DD Pearse - Frontiers in molecular neuroscience, 2016 - frontiersin.org
Following spinal cord injury (SCI), a multitude of intrinsic and extrinsic factors adversely
affect the gene programs that govern the expression of regeneration-associated genes …
affect the gene programs that govern the expression of regeneration-associated genes …
[HTML][HTML] Neuronal involvement in muscular atrophy
BA Cisterna, C Cardozo, JC Sáez - Frontiers in cellular neuroscience, 2014 - frontiersin.org
The innervation of skeletal myofibers exerts a crucial influence on the maintenance of
muscle tone and normal operation. Consequently, denervated myofibers manifest atrophy …
muscle tone and normal operation. Consequently, denervated myofibers manifest atrophy …